Skip to main content
NCBI home page
Infection and Immunity logoLink to Infection and Immunity
. 1981 Aug;33(2):636–640. doi: 10.1128/iai.33.2.636-640.1981

Restoration by Normal Human Immunoglobulin G of Deficient Serum Opsonization for Streptococcus pneumoniae in Sickle Cell Disease

Ann B Bjornson 1, Jeffrey S Lobel 2,3, Patricia I Magnafichi 1, Beatrice C Lampkin 2
PMCID: PMC350749  PMID: 7275323

Abstract

Supplementation of sera from four children with sickle cell disease with untreated or heated normal human serum or with normal human immunoglobulin G restored opsonic activity for serotype 10 Streptococcus pneumoniae, whereas supplementation with normal human immunoglobulin M did not.

Full text

PDF
636

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ammann A. J., Addiego J., Wara D. W., Lubin B., Smith W. B., Mentzer W. C. Polyvalent pneumococcal-polysaccharide immunization of patients with sickle-cell anemia and patients with splenectomy. N Engl J Med. 1977 Oct 27;297(17):897–900. doi: 10.1056/NEJM197710272971701. [DOI] [PubMed] [Google Scholar]
  2. Bjornson A. B., Gaston M. H., Zellner C. L. Decreased opsonization for Streptococcus pneumoniae in sickle cell disease: studies on selected complement components and immunoglobulins. J Pediatr. 1977 Sep;91(3):371–378. doi: 10.1016/s0022-3476(77)81303-6. [DOI] [PubMed] [Google Scholar]
  3. Bjornson A. B., Lobel J. S., Lampkin B. C. Humoral components of host defense in sickle cell disease during painful crisis and asymptomatic periods. J Pediatr. 1980 Feb;96(2):259–262. doi: 10.1016/s0022-3476(80)80818-3. [DOI] [PubMed] [Google Scholar]
  4. Corry J. M., Polhill R. B., Jr, Edmonds S. R., Johnston R. B., Jr Activity of the alternative complement pathway after splenectomy: comparison to activity in sickle cell disease and hypogammaglobulinemia. J Pediatr. 1979 Dec;95(6):964–969. doi: 10.1016/s0022-3476(79)80284-x. [DOI] [PubMed] [Google Scholar]
  5. FLODIN P., KILLANDER J. Fractionation of human-serum proteins by gel filtration. Biochim Biophys Acta. 1962 Oct 8;63:402–410. doi: 10.1016/0006-3002(62)90104-x. [DOI] [PubMed] [Google Scholar]
  6. Fearon D. T., Austen K. F. Activation of the alternative complement pathway due to resistance of zymosan-bound amplification convertase to endogenous regulatory mechanisms. Proc Natl Acad Sci U S A. 1977 Apr;74(4):1683–1687. doi: 10.1073/pnas.74.4.1683. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Fearon D. T., Austen K. F. Activation of the alternative complement pathway with rabbit erythrocytes by circumvention of the regulatory action of endogenous control proteins. J Exp Med. 1977 Jul 1;146(1):22–33. doi: 10.1084/jem.146.1.22. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Hand W. L., King N. L. Deficiency of serum bactericidal activity against Salmonella typhimurium in sickle cell anaemia. Clin Exp Immunol. 1977 Nov;30(2):262–270. [PMC free article] [PubMed] [Google Scholar]
  9. Hand W. L., King N. L. Serum opsonization of salmonella in sickle cell anemia. Am J Med. 1978 Mar;64(3):388–395. doi: 10.1016/0002-9343(78)90217-6. [DOI] [PubMed] [Google Scholar]
  10. Johnston R. B., Jr, Newman S. L., Struth A. G. An abnormality of the alternate pathway of complement activation in sickle-cell disease. N Engl J Med. 1973 Apr 19;288(16):803–808. doi: 10.1056/NEJM197304192881601. [DOI] [PubMed] [Google Scholar]
  11. Kazatchkine M. D., Fearon D. T., Silbert J. E., Austen K. F. Surface-associated heparin inhibits zymosan-induced activation of the human alternative complement pathway by augmenting the regulatory action of the control proteins on particle-bound C3b. J Exp Med. 1979 Nov 1;150(5):1202–1215. doi: 10.1084/jem.150.5.1202. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Koethe S. M., Casper J. T., Rodey G. E. Alternative complement pathway activity in sera from patients with sickle cell disease. Clin Exp Immunol. 1976 Jan;23(1):56–60. [PMC free article] [PubMed] [Google Scholar]
  13. Mancini G., Carbonara A. O., Heremans J. F. Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry. 1965 Sep;2(3):235–254. doi: 10.1016/0019-2791(65)90004-2. [DOI] [PubMed] [Google Scholar]
  14. O'Brien R. T., McIntosh S., Aspnes G. T., Pearson H. A. Prospective study of sickle cell anemia in infancy. J Pediatr. 1976 Aug;89(2):205–210. doi: 10.1016/s0022-3476(76)80449-0. [DOI] [PubMed] [Google Scholar]
  15. Pangburn M. K., Müller-Eberhard H. J. Complement C3 convertase: cell surface restriction of beta1H control and generation of restriction on neuraminidase-treated cells. Proc Natl Acad Sci U S A. 1978 May;75(5):2416–2420. doi: 10.1073/pnas.75.5.2416. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Pearson H. A., McIntosh S., Ritchey A. K., Lobel J. S., Rooks Y., Johnston D. Developmental aspects of splenic function in sickle cell diseases. Blood. 1979 Mar;53(3):358–365. [PubMed] [Google Scholar]
  17. Pearson H. A., Spencer R. P., Cornelius E. A. Functional asplenia in sickle-cell anemia. N Engl J Med. 1969 Oct 23;281(17):923–926. doi: 10.1056/NEJM196910232811703. [DOI] [PubMed] [Google Scholar]
  18. ROBBINS J. B., PEARSON H. A. NORMAL RESPONSE OF SICKLE CELL ANEMIA PATIENTS TO IMMUNIZATION WITH SALMONELLA VACCINES. J Pediatr. 1965 May;66:877–882. doi: 10.1016/s0022-3476(65)80062-2. [DOI] [PubMed] [Google Scholar]
  19. Schreiber R. D., Pangburn M. K., Lesavre P. H., Müller-Eberhard H. J. Initiation of the alternative pathway of complement: recognition of activators by bound C3b and assembly of the entire pathway from six isolated proteins. Proc Natl Acad Sci U S A. 1978 Aug;75(8):3948–3952. doi: 10.1073/pnas.75.8.3948. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Schwartz A. D., Pearson H. A. Impaired antibody response to intravenous immunization in sickle cell anemia. Pediatr Res. 1972 Feb;6(2):145–149. doi: 10.1203/00006450-197202000-00008. [DOI] [PubMed] [Google Scholar]
  21. Steinberg E., Overturf G. D., Portnoy B., Powars D. R., Boyer K. M., Cherry J. D. Serologic and clinical response of children with sickle cell disease to bivalent influenza A split virus vaccine. J Pediatr. 1978 May;92(5):823–825. doi: 10.1016/s0022-3476(78)80166-8. [DOI] [PubMed] [Google Scholar]
  22. Strauss R. G., Asbrock T., Forristal J., West C. D. Alternative pathway of complement in sickle cell disease. Pediatr Res. 1977 Apr;11(4):285–289. doi: 10.1203/00006450-197704000-00005. [DOI] [PubMed] [Google Scholar]
  23. Wilson W. A., Hughes G. R., Lachmann P. J. Deficiency of factor B of the complement system in sickle cell anaemia. Br Med J. 1976 Feb 14;1(6006):367–369. doi: 10.1136/bmj.1.6006.367. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Wilson W. A., Thomas E. J., Sissons J. G. Complement activation in asymptomatic patients with sickle cell anaemia. Clin Exp Immunol. 1979 Apr;36(1):130–139. [PMC free article] [PubMed] [Google Scholar]
  25. Winkelstein J. A., Drachman R. H. Deficiency of pneumococcal serum opsonizing activity in sickle-cell disease. N Engl J Med. 1968 Aug 29;279(9):459–466. doi: 10.1056/NEJM196808292790904. [DOI] [PubMed] [Google Scholar]
  26. Winkelstein J. A., Shin H. S. The role of immunoglobulin in the interaction of pneumococci and the properdin pathway: evidence for its specificity and lack of requirement for the Fc portion of the molecule. J Immunol. 1974 May;112(5):1635–1642. [PubMed] [Google Scholar]
  27. deCiutiis A. C., Peterson C. M., Polley M. J., Metakis L. J. Alternative pathway activation in sickle cell disease and beta-thalassemia major. J Natl Med Assoc. 1978 Jul;70(7):503–506. [PMC free article] [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES