Skip to main content
NCBI home page
Infection and Immunity logoLink to Infection and Immunity
. 1981 Sep;33(3):801–805. doi: 10.1128/iai.33.3.801-805.1981

Humoral immunity and reduced periodontal bone loss in Eikenella corrodens-monoassociated rats.

U H Behling, C Sallay, F Sanavi, P H Pham, A Nowotny
PMCID: PMC350782  PMID: 7026446

Abstract

Germfree Sprague-Dawley rats monoassociated with Eikenella corrodens exhibited alveolar bone loss. This progressive bone loss occurred over a period of weeks, during which time the hosts developed an immune response toward the infective microorganism. By means of repeated bacterial vaccination resulting in elevated serum antibody titers, reduced bone loss was observed.

Full text

PDF
801

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Baker J. J., Chan S. P., Socransky S. S., Oppenheim J. J., Mergenhagen S. E. Importance of Actinomyces and certain gram-negative anaerobic organisms in the transformation of lymphocytes from patients with periodontal disease. Infect Immun. 1976 May;13(5):1363–1368. doi: 10.1128/iai.13.5.1363-1368.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Brandtzaeg P., Baklien K. Immunohistochemical studies of the formation and epithelial transport of immunoglobulins in normal and diseased human intestinal mucosa. Scand J Gastroenterol Suppl. 1976;36:1–45. [PubMed] [Google Scholar]
  3. Brandtzaeg P., Tolo K. Mucosal penetrability enhanced by serum-derived antibodies. Nature. 1977 Mar 17;266(5599):262–263. doi: 10.1038/266262a0. [DOI] [PubMed] [Google Scholar]
  4. Chandler D. C., Silverman M. S., Lundblad R. L., McFall W. T. Human parotid IgA and periodontal disease. Arch Oral Biol. 1974 Aug;19(8):733–735. doi: 10.1016/0003-9969(74)90144-7. [DOI] [PubMed] [Google Scholar]
  5. Coykendall A. L., Kaczmarek F. S. DNA homologies among Eikenella corrodens strains. J Periodontal Res. 1980 Nov;15(6):615–620. doi: 10.1111/j.1600-0765.1980.tb00320.x. [DOI] [PubMed] [Google Scholar]
  6. Crawford J. M., Taubman M. A., Smith D. J. The effects of local immunization with periodontopathic microorganisms on periodontal bone loss in gnotobiotic rats. J Periodontal Res. 1978 Sep;13(5):445–459. doi: 10.1111/j.1600-0765.1978.tb00198.x. [DOI] [PubMed] [Google Scholar]
  7. Crawford J. M., Taubman M. A., Smith D. J. The natural history of periodontal bone loss in germfree and gnotobiotic rats infected with periodontopathic microorganisms. J Periodontal Res. 1978 Jul;13(4):316–325. doi: 10.1111/j.1600-0765.1978.tb00186.x. [DOI] [PubMed] [Google Scholar]
  8. Guggenheim B., Schroeder H. E. Reactions in the periodontium to continuous antigenic stimulation in sensitized gnotobiotic rats. Infect Immun. 1974 Sep;10(3):565–577. doi: 10.1128/iai.10.3.565-577.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Holmberg K., Killander J. Quantitative determination of immunoglobuline (IgG, IgA and IgM) and identification of IgA-type in the gingival fluid. J Periodontal Res. 1971;6(1):1–8. doi: 10.1111/j.1600-0765.1971.tb00581.x. [DOI] [PubMed] [Google Scholar]
  10. Horton J. E., Leikin S., Oppenheim J. J. Human lymphoproliferative reaction to saliva and dental plaque-deposits: an in vitro correlation with periodontal disease. J Periodontol. 1972 Sep;43(9):522–527. doi: 10.1902/jop.1972.43.9.522. [DOI] [PubMed] [Google Scholar]
  11. Ivanyi L., Lehner T. Lymphocyte transformation by sonicates of dental plaque in human periodontal disease. Arch Oral Biol. 1971 Sep;16(9):1117–1121. doi: 10.1016/0003-9969(71)90216-0. [DOI] [PubMed] [Google Scholar]
  12. Ivanyi L., Lehner T. Stimulation of lymphocyte transformation by bacterial antigens in patients with periodontal disease. Arch Oral Biol. 1970 Nov;15(11):1089–1096. doi: 10.1016/0003-9969(70)90121-4. [DOI] [PubMed] [Google Scholar]
  13. Johnson D. A., Behling U. H., Lai C. H., Listgarten M., Socransky S., Nowotny A. Role of bacterial products in periodontitis: immune response in gnotobiotic rats monoinfected with Eikenella corrodens. Infect Immun. 1978 Jan;19(1):246–253. doi: 10.1128/iai.19.1.246-253.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Johnson D. A., Behling U. H., Listgarten M., Nowotny A. Role of bacterial products in periodontitis: humoral immune response to Eikenella corrodens. Infect Immun. 1978 Nov;22(2):382–386. doi: 10.1128/iai.22.2.382-386.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Listgarten M. A., Johnson D., Nowotny A., Tanner A. C., Socransky S. S. Histopathology of periodontal disease in gnotobiotic rats monoinfected with Eikenella corrodens. J Periodontal Res. 1978 Mar;13(2):134–148. doi: 10.1111/j.1600-0765.1978.tb00162.x. [DOI] [PubMed] [Google Scholar]
  16. McDougall W. A. The effect of topical antigen on the gingiva of sensitized rabbits. J Periodontal Res. 1974;9(3):153–164. doi: 10.1111/j.1600-0765.1974.tb00667.x. [DOI] [PubMed] [Google Scholar]
  17. McGhee, Michalek S. M., Webb J., Navia J. M., Rahman A. F., Legler D. W. Effective immunity to dental caries: protection of gnotobiotic rats by local immunization with Streptococcus mutans. J Immunol. 1975 Jan;114(1 Pt 2):300–305. [PubMed] [Google Scholar]
  18. Pincus W. B. Cell-free cytotoxic fluids from tuberculin-treated guinea pigs. J Reticuloendothel Soc. 1967 May;4(2):140–150. [PubMed] [Google Scholar]
  19. Ruddle N. H., Waksman B. H. Cytotoxicity mediated by soluble antigen and lymphocytes in delayed hypersensitivity. I. Characterization of the phenomenon. J Exp Med. 1968 Dec 1;128(6):1237–1254. doi: 10.1084/jem.128.6.1237. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Rylander H., Lindhe J., Ahlstedt S. Experimental gingivitis in immunized dogs. J Periodontal Res. 1976 Nov;11(6):339–348. doi: 10.1111/j.1600-0765.1976.tb00088.x. [DOI] [PubMed] [Google Scholar]
  21. Schwartz J., Stinson F. L., Parker R. B. The passage of tritiated bacterial endotoxin across intact gingival crevicular epithelium. J Periodontol. 1972 May;43(5):270–276. doi: 10.1902/jop.1972.43.5.270. [DOI] [PubMed] [Google Scholar]
  22. Taubman M. A., Smith D. J. Effects of local immunization with glucosyltransferase fractions from Streptococcus mutans on dental caries in rats and hamsters. J Immunol. 1977 Feb;118(2):710–720. [PubMed] [Google Scholar]
  23. Tomasi T. B., Jr Structure and function of mucosal antibodies. Annu Rev Med. 1970;21:281–298. doi: 10.1146/annurev.me.21.020170.001433. [DOI] [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES