Abstract
The currently United States-licensed group C Neisseria meningitidis vaccine, composed of the O-acetyl-positive capsular polysaccharide, is poorly immunogenic and does not afford protection from disease to infants and young children. Group C N. meningitidis O-acetyl-negative polysaccharide vaccine induces higher titers in adults than does the O-acetyl-positive vaccine. We compared the immunogenicity of these vaccines in 2-year-old children. Reactions were minimal and did not differ between the two vaccines. The postvaccination geometric mean titer was twofold greater in the O-acetyl-negative group (1.58 versus 0.73 micrograms of antibody per ml). The rates of decline in titer were similar in both groups. Further study regarding immunogenicity of and the anamnestic response to the O-acetyl-negative vaccine is warranted in the age group (less than 18 months) at highest risk for invasive meningococcal disease.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Amato Neto V., Finger H., Gotschlich E. C., Feldman R. A., de Avila C. A., Konichi S. R., Laus W. C. Serologic response to serogroup C meningococcal vaccine in Brazilian preschool children. Rev Inst Med Trop Sao Paulo. 1974 May-Jun;16(3):149–153. [PubMed] [Google Scholar]
- Glode M. P., Lewin E. B., Sutton A., Le C. T., Gotschlich E. C., Robbins J. B. Comparative immunogenicity of vaccines prepared from capsular polysaccharides of group C Neisseria meningitidis O-acetyl-positive and O-acetyl-negative variants and Escherichia coli K92 in adult volunteers. J Infect Dis. 1979 Jan;139(1):52–59. doi: 10.1093/infdis/139.1.52. [DOI] [PubMed] [Google Scholar]
- Gold R., Artenstein M. S. Meningococcal infections. 2. Field trial of group C meningococcal polysaccharide vaccine in 1969-70. Bull World Health Organ. 1971;45(3):279–282. [PMC free article] [PubMed] [Google Scholar]
- Gold R., Lepow M. L., Goldschneider I., Draper T. F., Gotshlich E. C. Kinetics of antibody production to group A and group C meningococcal polysaccharide vaccines administered during the first six years of life: prospects for routine immunization of infants and children. J Infect Dis. 1979 Nov;140(5):690–697. doi: 10.1093/infdis/140.5.690. [DOI] [PubMed] [Google Scholar]
- Gold R., Lepow M. L., Goldschneider I., Gotschlich E. C. Immune Response of human infants of polysaccharide vaccines of group A and C Neisseria meningitidis. J Infect Dis. 1977 Aug;136 (Suppl):S31–S35. doi: 10.1093/infdis/136.supplement.s31. [DOI] [PubMed] [Google Scholar]
- Goldschneider I., Gotschlich E. C., Artenstein M. S. Human immunity to the meningococcus. I. The role of humoral antibodies. J Exp Med. 1969 Jun 1;129(6):1307–1326. doi: 10.1084/jem.129.6.1307. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gotschlich E. C., Rey M., Triau R., Sparks K. J. Quantitative determination of the human immune response to immunization with meningococcal vaccines. J Clin Invest. 1972 Jan;51(1):89–96. doi: 10.1172/JCI106801. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Jennings H. J., Bhattacharjee A. K., Bundle D. R., Kenny C. P., Martin A., Smith I. C. Strucutres of the capsular polysaccharides of Neisseria meningitidis as determined by 13C-nuclear magnetic resonance spectroscopy. J Infect Dis. 1977 Aug;136 (Suppl):S78–S83. doi: 10.1093/infdis/136.supplement.s78. [DOI] [PubMed] [Google Scholar]
- Wong K. H., Barrera O., Sutton A., May J., Hochstein D. H., Robbins J. D., Robbins J. B., Parkman P. D., Seligmann E. B., Jr Standardization and control of meningococcal vaccines, group A and group C polysaccharides. J Biol Stand. 1977;5(3):197–215. doi: 10.1016/s0092-1157(77)80005-x. [DOI] [PubMed] [Google Scholar]