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. 1981 Oct;34(1):171–176. doi: 10.1128/iai.34.1.171-176.1981

Effects of pneumolysin on human polymorphonuclear leukocytes and platelets.

M K Johnson, D Boese-Marrazzo, W A Pierce Jr
PMCID: PMC350839  PMID: 7298179

Abstract

Pneumolysin was bound by human polymorphonuclear leukocytes in a reaction which occurred very rapidly at 0 degrees C. Low concentrations of pneumolysin were found to stimulate leukocyte migration and lysosomal enzyme secretion. At increasing lysin levels, inhibition of spontaneous migration and chemotaxis, cell death, and lysis were observed. Pneumolysin was also found to lyse platelets and to activate serum to become chemotactic.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Andersen B. R., Van Epps D. E. Suppression of chemotatic activity of human neutrophils by streptolysin O. J Infect Dis. 1972 Apr;125(4):353–359. doi: 10.1093/infdis/125.4.353. [DOI] [PubMed] [Google Scholar]
  2. Johnson M. K., Allen J. H. The role of cytolysin in pneumococcal ocular infection. Am J Ophthalmol. 1975 Sep;80(3 Pt 2):518–521. doi: 10.1016/0002-9394(75)90219-6. [DOI] [PubMed] [Google Scholar]
  3. Johnson M. K., Geoffroy C., Alouf J. E. Binding of cholesterol by sulfhydryl-activated cytolysins. Infect Immun. 1980 Jan;27(1):97–101. doi: 10.1128/iai.27.1.97-101.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Johnson M. K. Properties of purified pneumococcal hemolysin. Infect Immun. 1972 Nov;6(5):755–760. doi: 10.1128/iai.6.5.755-760.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Launay J. M., Alouf J. E. Biochemical and ultrastructural study of the disruption of blood platelets by streptolysin O. Biochim Biophys Acta. 1979 Sep 21;556(2):278–291. doi: 10.1016/0005-2736(79)90048-8. [DOI] [PubMed] [Google Scholar]
  6. WEISSMANN G., KEISER H., BERNHEIMER A. W. STUDIES ON LYSOSOMES. III. THE EFFECTS OF STREPTOLYSINS O AND S ON THE RELEASE OF ACID HYDROLASES FROM A GRANULAR FRACTION OF RABBIT LIVER. J Exp Med. 1963 Aug 1;118:205–222. doi: 10.1084/jem.118.2.205. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Ward P. A., Lepow I. H., Newman L. J. Bacterial factors chemotactic for polymorphonuclear leukocytes. Am J Pathol. 1968 Apr;52(4):725–736. [PMC free article] [PubMed] [Google Scholar]
  8. Wilkinson P. C. Inhibition of leukocyte locomotion and chemotaxis by lipid-specific bacterial toxins. Nature. 1975 Jun 5;255(5508):485–487. doi: 10.1038/255485a0. [DOI] [PubMed] [Google Scholar]
  9. Woodin A. M., Wieneke A. A. The secretion of protein by the polymorphonuclear leucocyte treated with streptolysin O. Exp Cell Res. 1966 Sep;43(2):319–331. doi: 10.1016/0014-4827(66)90059-0. [DOI] [PubMed] [Google Scholar]
  10. ZUCKER-FRANKLIN D. ELECTRON MICROSCOPE STUDY OF THE DEGRANULATION OF POLYMORPHONUCLEAR LEUKOCYTES FOLLOWING TREATMENT WITH STREPTOLYSIN. Am J Pathol. 1965 Sep;47:419–433. [PMC free article] [PubMed] [Google Scholar]

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