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. 1981 Nov;34(2):492–497. doi: 10.1128/iai.34.2.492-497.1981

Vaccinal properties of Salmonella abortus ovis mutants for streptomycin: screening with a murine model.

F Lantier, P Pardon, J Marly
PMCID: PMC350893  PMID: 7309235

Abstract

Streptomycin-dependent and streptomycin-independent reverse mutants of Salmonella abortus ovis were selected on medium with and without added streptomycin. Their in vivo properties were tested with a murine model. Reduced capacities of dissemination and multiplication of all mutant strains were evidenced by means of subcutaneous, intraperitoneal, and intravenous inoculations of two outbred strains of mice with different susceptibilities to experimental S. abortus ovis infection. A factorial immunization experiment demonstrated the effects of vaccinal strains and doses. It showed large differences among the mutants. First-time infection with the fully virulent parent strain excepted, the best protection was given by independent reverse mutants which had kept residual capacity of in vivo dissemination and multiplication. This screening partly determined the selection of strain Rv6 as a potential live vaccine.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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