Skip to main content
NCBI home page
Infection and Immunity logoLink to Infection and Immunity
. 1981 Nov;34(2):498–502. doi: 10.1128/iai.34.2.498-502.1981

Enhanced immunoglobulin, A release from human colostral cells during phagocytosis.

E A Weaver, R M Goldblum, C P Davis, A S Goldman
PMCID: PMC350894  PMID: 7030962

Abstract

Human colostral leukocytes were investigated for their ability to release immunoglobulin A during phagocytosis of latex particles, heat-killed Candida albicans, or live Escherichia coli. Leukocytes readily phagocytosed latex or serum-opsonized candida or the E. coli. Colostral fluid was also opsonic for yeast and bacteria. Immunoglobulin release, which consisted mainly of secretory immunoglobulin A, began during the first 15 min of incubation with latex, opsonized yeast, or opsonized bacteria. Release was significantly increased from control levels by 30 or 60 min. The release of immunoglobulin A could be inhibited by incubating leukocytes at 4 degrees C. We conclude that phagocytosis and immunoglobulin A release by human colostral leukocytes are related. The data support the hypothesis that colostral leukocytes may play an active role in protecting infants from pathogenic microorganisms.

Full text

PDF
498

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ahlstedt S., Carlsson B., Hanson L. A., Goldblum R. M. Antibody production by human colostral cells. I. Immunoglobulin class, specificity, and quantity. Scand J Immunol. 1975 Sep;4(5-6):535–539. doi: 10.1111/j.1365-3083.1975.tb02659.x. [DOI] [PubMed] [Google Scholar]
  2. Crago S. S., Prince S. J., Pretlow T. G., McGhee J. R., Mestecky J. Human colostral cells. I. Separation and characterization. Clin Exp Immunol. 1979 Dec;38(3):585–597. [PMC free article] [PubMed] [Google Scholar]
  3. Cunningham A. S. Morbidity in breast-fed and artificially fed infants. II. J Pediatr. 1979 Nov;95(5 Pt 1):685–689. doi: 10.1016/s0022-3476(79)80711-8. [DOI] [PubMed] [Google Scholar]
  4. Edén C. S., Carlsson B., Hanson L. A., Jann B., Jann K., Korhonen T., Wadström T. Anti-pili antibodies in breast milk. Lancet. 1979 Dec 8;2(8154):1235–1235. doi: 10.1016/s0140-6736(79)92348-1. [DOI] [PubMed] [Google Scholar]
  5. France G. L., Marmer D. J., Steele R. W. Breast-feeding and Salmonella infection. Am J Dis Child. 1980 Feb;134(2):147–152. doi: 10.1001/archpedi.1980.02130140021007. [DOI] [PubMed] [Google Scholar]
  6. Goldblum R. M., Powell G. K., Van Sickle G. Secretory IgA in the serum of infants with obstructive jaundice. J Pediatr. 1980 Jul;97(1):33–36. doi: 10.1016/s0022-3476(80)80125-9. [DOI] [PubMed] [Google Scholar]
  7. Goldblum R. M., Van Bavel J. Immunoglobulin A production by human colostral cells: quantitative aspects. Adv Exp Med Biol. 1978;107:87–94. doi: 10.1007/978-1-4684-3369-2_11. [DOI] [PubMed] [Google Scholar]
  8. Murillo G. J., Goldman A. S. The cells of human colostrum. II. Synthesis of IgA and Beta1c. Pediatr Res. 1970 Jan;4(1):71–75. doi: 10.1203/00006450-197001000-00008. [DOI] [PubMed] [Google Scholar]
  9. Nagy L. K., Bhogal B. S., Mackenzie T. Duration of anti-adhesive and bactericidal activities of milk from vaccinated sows on Escherichia coli O149 in the digestive tract of piglets during the nursing period. Res Vet Sci. 1979 Nov;27(3):289–296. [PubMed] [Google Scholar]
  10. Ofek I., Beachey E. H., Jefferson W., Campbell G. L. Cell membrane-binding properties of group A streptococcal lipoteichoic acid. J Exp Med. 1975 May 1;141(5):990–1003. doi: 10.1084/jem.141.5.990. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Pickering L. K., Cleary T. G., Kohl S., Getz S. Polymorphonuclear leukocytes of human colostrum. I. Oxidative metabolism and kinetics of killing of radiolabeled Staphylococcus aureus. J Infect Dis. 1980 Nov;142(5):685–693. doi: 10.1093/infdis/142.5.685. [DOI] [PubMed] [Google Scholar]
  12. Pittard W. B., 3rd, Polmar S. H., Fanaroff A. A. The breastmilk macrophage: a potential vehicle for immunoglobulin transport. J Reticuloendothel Soc. 1977 Dec;22(6):597–603. [PubMed] [Google Scholar]
  13. Robinson J. E., Harvey B. A., Soothill J. F. Phagocytosis and killing of bacteria and yeast by human milk cells after opsonisation in aqueous phase of milk. Br Med J. 1978 Jun 3;1(6125):1443–1445. doi: 10.1136/bmj.1.6125.1443. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Smith C. W., Goldman A. S. The cells of human colostrum. I. In vitro studies of morphology and functions. Pediatr Res. 1968 Mar;2(2):103–109. doi: 10.1203/00006450-196803000-00005. [DOI] [PubMed] [Google Scholar]
  15. Tomasi T. B., Grey H. M. Structure and function of immunoglobulin A. Prog Allergy. 1972;16:81–213. [PubMed] [Google Scholar]
  16. Yam L. T., Li C. Y., Crosby W. H. Cytochemical identification of monocytes and granulocytes. Am J Clin Pathol. 1971 Mar;55(3):283–290. doi: 10.1093/ajcp/55.3.283. [DOI] [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES