Abstract
Marmosets infected intracerebrally with the wild Edmonston strain of measles virus developed encephalitis, demonstrated histologically and by the fluorescent-antibody technique. The infection remained clinically silent over a 14-day observation period. Animals infected intracerebrally with the JM strain of wild measles virus had only mild encephalitic changes but died of the visceral form of measles infection. Marmosets inoculated with measles vaccine had no encephalitis and remained clinically well. Marmosets appear to be a sensitive indicator of the viscerotropic and neurotropic properties of measles virus.
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- Albrecht P., Burnstein T., Klutch M. J., Hicks H. T., Ennis F. A. Subacute sclerosing panencephalitis: experimental infection in primates. Science. 1977 Jan 7;195(4273):64–66. doi: 10.1126/science.831255. [DOI] [PubMed] [Google Scholar]
- Albrecht P. Immune control in experimental subacute sclerosing panencephalitis. Am J Clin Pathol. 1978 Jul;70(1 Suppl):175–184. [PubMed] [Google Scholar]
- Albrecht P., Lorenz D., Klutch M. J., Vickers J. H., Ennis F. A. Fatal measles infection in marmosets pathogenesis and prophylaxis. Infect Immun. 1980 Mar;27(3):969–978. doi: 10.1128/iai.27.3.969-978.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Albrecht P., Shabo A. L., Burns G. R., Tauraso N. M. Experimental measles encephalitis in normal and cyclophosphamide-treated rhesus monkeys. J Infect Dis. 1972 Aug;126(2):154–161. doi: 10.1093/infdis/126.2.154. [DOI] [PubMed] [Google Scholar]
- ENDERS J. F., KATZ S. L., MILOVANOVIC M. V., HOLLOWAY A. Studies on an attenuated measles-virus vaccine. I. Development and preparations of the vaccine: technics for assay of effects of vaccination. N Engl J Med. 1960 Jul 28;263:153–159. doi: 10.1056/NEJM196007282630401. [DOI] [PubMed] [Google Scholar]
- GIBBS F. A., GIBBS E. L., CARPENTER P. R., SPIES H. W. Electroencephalographic abnormality in "uncomplicated" childhood diseases. J Am Med Assoc. 1959 Oct 24;171:1050–1055. doi: 10.1001/jama.1959.03010260006002. [DOI] [PubMed] [Google Scholar]
- Hicks J. T., Sullivan J. L., Albrecht P. Immune responses during measles infection in immunosuppressed Rhesus monkeys. J Immunol. 1977 Oct;119(4):1452–1456. [PubMed] [Google Scholar]
- Hilleman M. R., Buynak E. B., Weibel R. E., Stokes J., Jr, Whitman J. E., Jr, Leagus M. B. Development and evaluation of the Moraten measles virus vaccine. JAMA. 1968 Oct 14;206(3):587–590. [PubMed] [Google Scholar]
- Horta-Barbosa L., Fuccillo D. A., Hamilton R., Traub R., Ley A., Sever J. L. Some characteristics of SSPE measles virus. Proc Soc Exp Biol Med. 1970 May;134(1):17–21. doi: 10.3181/00379727-134-34718. [DOI] [PubMed] [Google Scholar]
- Lorenz D., Albrecht P. Susceptibility of tamarins (Saguinus) to measles virus. Lab Anim Sci. 1980 Aug;30(4 Pt 1):661–665. [PubMed] [Google Scholar]
- MEYER H. M., Jr, BROOKS B. E., DOUGLAS R. D., ROGERS N. G. Ecology of measles in monkeys. Am J Dis Child. 1962 Mar;103:307–313. doi: 10.1001/archpedi.1962.02080020319025. [DOI] [PubMed] [Google Scholar]
- Potkay S., Ganaway J. R., Rogers N. G., Kinard R. An epizootic of measles in a colony of rhesus monkeys (Macaca mulatta). Am J Vet Res. 1966 Jan;27(116):331–334. [PubMed] [Google Scholar]
- Schumacher H. P., Albrecht P., Clark R. G., Kirschstein R. L., Tauraso N. M. Intracerebral inoculation of rhesus monkeys with a strain of measles virus isolated from a case of subacute sclerosing panencephalitis. Infect Immun. 1971 Oct;4(4):419–424. doi: 10.1128/iai.4.4.419-424.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]