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. 1981 Nov;34(2):588–595. doi: 10.1128/iai.34.2.588-595.1981

Effects of lectins on peripheral infections by herpes simplex virus of rat sensory neurons in culture.

R J Ziegler, R S Pozos
PMCID: PMC350907  PMID: 6273322

Abstract

Concanavalin A and wheat germ agglutinin are capable of preventing a productive peripheral infection of dissociated rat sensory neurons in culture by herpes simplex virus type 1. Concanavalin A binds to the herpes simplex virion, rendering it inactive, whereas wheat germ agglutinin binds to the peripheral neuritic extensions of the sensory neurons, rendering them incapable of initiating a productive viral infection. This latter effect (i) seems to be specific for wheat germ agglutinin since other lectins have no effect, (ii) is not the result of cellular cytotoxicity, (iii) is dependent on an N-acetylneuraminic acid moiety, and (iv) may be due either to viral receptor site masking or to binding of wheat germ agglutinin to the neuritic receptor molecule for herpes simplex virus.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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