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. 1981 Dec;34(3):993–999. doi: 10.1128/iai.34.3.993-999.1981

Epithelioid granuloma induced by muramyl dipeptide in immunologically deficient rats.

S Nagao, F Ota, K Emori, K Inoue, A Tanaka
PMCID: PMC350966  PMID: 6977492

Abstract

When WKA rats were either neonatally thymectomized or injected with anti-rat thymocyte sera, their T-cell functions were effectively suppressed. When neonatally thymectomized plus anti-rat thymocyte serum-treated rats were injected with non-immunogenic muramyl dipeptide in water-in-oil emulsion, they produced massive epithelioid granulomas. Essentially, no morphological difference was noticed between granulomas induced in untreated rats and in thymectomized plus anti-rat thymocyte serum-treated rats. These findings strongly suggest that muramyl dipeptide-induced epithelioid granulomas required no T cells for their formation. In contrast, the induction of adjuvant arthritis appeared to depend on the presence of T cells.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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