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. 1982 Jan;35(1):52–57. doi: 10.1128/iai.35.1.52-57.1982

Genetic control of Propionibacterium acnes-induced protection of mice against Babesia microti.

P R Wood, I A Clark
PMCID: PMC350994  PMID: 7054129

Abstract

Using various strains of inbred mice, we found that Propionibacterium acnes-induced protection against the hemoprotozoan parasite Babesia microti was controlled by a dominant gene(s) not linked to the major histocompatibility gene (H2) complex of mice. P. acnes-induced resistance to infection was not merely an amplification of the normal immune response to B. microti, since innate resistance to infection was controlled by different genes. Expression of the nonspecific protection induced by P. acnes was found to be transferable with cells of bone marrow origin, and it did not necessarily accompany the induction of hepatosplenomegaly. The implication of these results for the understanding of the mechanism of P. acnes-induced protection is discussed.

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Selected References

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  1. Adlam C., Broughton E. S., Scott M. T. Enhanced resistance of mice to infection with bacteria following pre-treatment with Corynebacterium parvum. Nat New Biol. 1972 Feb 16;235(59):219–220. doi: 10.1038/newbio235219a0. [DOI] [PubMed] [Google Scholar]
  2. Adlam C., Scott M. T. Lympho-reticular stimulatory properties of Corynebacterium parvum and related bacteria. J Med Microbiol. 1973 Aug;6(3):261–274. doi: 10.1099/00222615-6-3-261. [DOI] [PubMed] [Google Scholar]
  3. Bradley D. J. Letter: Genetic control of natural resistance to Leishmania donovani. Nature. 1974 Jul 26;250(464):353–354. doi: 10.1038/250353a0. [DOI] [PubMed] [Google Scholar]
  4. Civil R. H., Mahmoud A. A. Genetic differences in BCG-induced resistance to Schistosoma mansoni are not controlled by genes within the major histocompatibility complex of the mouse. J Immunol. 1978 Mar;120(3):1070–1072. [PubMed] [Google Scholar]
  5. Clark I. A., Cox F. E., Allison A. C. Protection of mice against Babesia spp. and Plasmodium spp. with killed Corynebacterium parvum. Parasitology. 1977 Feb;74(1):9–18. doi: 10.1017/s003118200004748x. [DOI] [PubMed] [Google Scholar]
  6. Collins F. M., Scott M. T. Effect of Corynebacterium parvum treatment on the growth of Salmonella enteritidis in mice. Infect Immun. 1974 May;9(5):863–869. doi: 10.1128/iai.9.5.863-869.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Cottrell B. J., Playfair J. H., de Sousa B. Plasmodium yoelii and Plasmodium vinckei: the effects of nonspecific immunostimulation on murine malaria. Exp Parasitol. 1977 Oct;43(1):45–53. doi: 10.1016/0014-4894(77)90006-6. [DOI] [PubMed] [Google Scholar]
  8. Diesselhoff-den Dulk M. M., Crofton R. W., van Furth R. Origin and kinetics of Kupffer cells during an acute inflammatory response. Immunology. 1979 May;37(1):7–14. [PMC free article] [PubMed] [Google Scholar]
  9. Eling W., van Zon A., Jerusalem C. The course of a Plasmodium berghei infection in six different mouse strains. Z Parasitenkd. 1977 Dec 13;54(1):29–45. doi: 10.1007/BF00380634. [DOI] [PubMed] [Google Scholar]
  10. HALPERN B. N., PREVOT A. R., BIOZZI G., STIFFEL C., MOUTON D., MORARD J. C., BOUTHILLIER Y., DECREUSEFOND C. STIMULATION DE L'ACTIVIT'E PHAGOCYTAIRE DU SYST'EME R'ETICULOENDOTH'ELIAL PROVOQU'EE PAR CORYNEBACTERIUM PARVUM. J Reticuloendothel Soc. 1964 Jan;1:77–96. [PubMed] [Google Scholar]
  11. Hirst R. G., Campbell R. Mechanisms of resistance to Corynebacterium kutscheri in mice. Infect Immun. 1977 Aug;17(2):319–324. doi: 10.1128/iai.17.2.319-324.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Hirst R. G., Wallace M. E. Inherited resistance to Corynebacterium kutscheri in mice. Infect Immun. 1976 Aug;14(2):475–482. doi: 10.1128/iai.14.2.475-482.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Kierszenbaum F. Enhancement of resistance and suppression of immunization against experimental Trypanosoma cruzi infection by Corynebacterium parvum. Infect Immun. 1975 Nov;12(5):1227–1229. doi: 10.1128/iai.12.5.1227-1229.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Kirchner H., Scott M. T., Hirt H. M., Munk K. Protection of mice against viral infection by Corynebacterium parvum and Bordetella pertussis. J Gen Virol. 1978 Oct;41(1):97–104. doi: 10.1099/0022-1317-41-1-97. [DOI] [PubMed] [Google Scholar]
  15. Kobayashi F., Nagoya T., Koshi T., Saino Y. Biphasic protection against bacterial infection in mice induced by vaccination of Propionibacterium acnes. Infect Immun. 1980 Feb;27(2):391–396. doi: 10.1128/iai.27.2.391-396.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Lodmell D. L., Ewalt L. C. Induction of enhanced resistance against encephalomyocarditis virus infection of mice by nonviable Mycobacterium tuberculosis: mechanisms of protection. Infect Immun. 1978 Dec;22(3):740–745. doi: 10.1128/iai.22.3.740-745.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. MacVittie T. J. Alterations induced in macrophage and granulocyte-macrophage colony-forming cells by a single injection of mice with Corynebacterium parvum. J Reticuloendothel Soc. 1979 Nov;26(5):479–490. [PubMed] [Google Scholar]
  18. Milas L., Scott M. T. Antitumor activity of Corynebacterium parvum. Adv Cancer Res. 1978;26:257–306. doi: 10.1016/s0065-230x(08)60090-1. [DOI] [PubMed] [Google Scholar]
  19. Miller L. H., Carter R. A review. Innate resistance in malaria. Exp Parasitol. 1976 Aug;40(1):132–146. doi: 10.1016/0014-4894(76)90075-8. [DOI] [PubMed] [Google Scholar]
  20. Mitchell G. F., Rajasekariah G. R., Rickard M. D. A mechanism to account for mouse strain variation in resistance to the larval cestode, Taenia taeniaeformis. Immunology. 1980 Apr;39(4):481–489. [PMC free article] [PubMed] [Google Scholar]
  21. Nussenzweig R. S. Increased nonspecific resstance to malaria produced by administration of killed Corynebacterium parvum. Exp Parasitol. 1967 Oct;21(2):224–231. doi: 10.1016/0014-4894(67)90084-7. [DOI] [PubMed] [Google Scholar]
  22. Otu A. A., Russell R. J., White R. G. Biphasic pattern of activation of the reticuloendothelial system by anaerobic coryneforms in mice. Immunology. 1977 Mar;32(3):255–264. [PMC free article] [PubMed] [Google Scholar]
  23. PIERCE-CHASE C. H., FAUVE R. M., DUBOS R. CORYNEBACTERIAL PSEUDOTUBERCULOSIS IN MICE. I. COMPARATIVE SUSCEPTIBILITY OF MOUSE STRAINS TO EXPERIMENTAL INFECTION WITH CORYNEBACTERIUM KUTSCHERI. J Exp Med. 1964 Aug 1;120:267–281. doi: 10.1084/jem.120.2.267. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Riveros-Moreno V., Niblock A. Chemical properties of the principle in C. parvum that produces splenomegaly in mice. Immunology. 1979 Mar;36(3):495–499. [PMC free article] [PubMed] [Google Scholar]
  25. Robson H. G., Vas S. I. Resistance of inbred mice to Salmonella typhimurium. J Infect Dis. 1972 Oct;126(4):378–386. doi: 10.1093/infdis/126.4.378. [DOI] [PubMed] [Google Scholar]
  26. Roszkowski W., Ko H. L., Roszkowski K., Szmigielski S., Jeljaszewicz J., Pulverer G. The correlation of susceptibility of different Propionibacterium strains to macrophage killing and antitumor activity. Med Microbiol Immunol. 1980;169(1):1–8. doi: 10.1007/BF02123706. [DOI] [PubMed] [Google Scholar]
  27. Ruebush M. J., Hanson W. L. Susceptibility of five strains of mice to Babesia microti of human origin. J Parasitol. 1979 Jun;65(3):430–433. [PubMed] [Google Scholar]
  28. Sadler T. E., Cramp W. A., Castro J. E. Radiolabelling of Corynebacterium parvum and its distribution in mice. Br J Cancer. 1977 Mar;35(3):357–368. doi: 10.1038/bjc.1977.50. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Scott M. T., Milas L. The distribution and persistence in vivo of Corynebacterium parvum in relation to its antitumor activity. Cancer Res. 1977 Jun;37(6):1673–1679. [PubMed] [Google Scholar]
  30. Sher N. A., Chaparas S. D., Greenberg L. E., Bernard S. Effects of BCG, Corynebacterium parvum, and methanol-extration residue in the reduction of mortality from Staphylococcus aureus and Candida albicans infections in immunosuppressed mice. Infect Immun. 1975 Dec;12(6):1325–1330. doi: 10.1128/iai.12.6.1325-1330.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  31. Skamene E., Kongshavn P. A., Sachs D. H. Resistance to Listeria monocytogenes in mice: genetic control by genes that are not linked to the H-2 complex. J Infect Dis. 1979 Feb;139(2):228–231. doi: 10.1093/infdis/139.2.228. [DOI] [PubMed] [Google Scholar]
  32. Stiffel C., Mouton D., Bouthillier Y., Decreusefond C., Biozzi G. Réponse du SRE au Mycobacterium tuberculosis (BCG) et au Corynebacterium parvum chez des souris de différentes lignées. J Reticuloendothel Soc. 1970 Feb;7(2):280–293. [PubMed] [Google Scholar]

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