Skip to main content
PMC home page
Infection and Immunity logoLink to Infection and Immunity
. 1982 Jan;35(1):111–116. doi: 10.1128/iai.35.1.111-116.1982

Response of CBA/N x DBA2/F1 mice to Nocardia asteroides.

B L Beaman, M E Gershwin, A Ahmed, S M Scates, R Deem
PMCID: PMC351003  PMID: 7033133

Abstract

Immunized and nonimmunized B-lymphocyte-deficient CBD2/F1 (CBA/N x DBA/2) mice were infected with Nocardia asteroides GUH-2 by different routes of inoculation. The 50% lethal dose, organ clearance, footpad response, and antibody titers were measured. It was observed that B-cell-deficient male mice were not significantly more susceptible to infection than normal female controls even though the female CBD2/F1 mice produced antinocardial antibodies while the deficient male animals did not. Preimmunized male and female mice were identical in their ability to clear N. asteroides from the adrenals, brain, kidneys, liver, lungs, and spleen. Both DBA/2 and CBD2/F1 female mice were more susceptible than their male littermates to intravenous challenge with N. asteroides GUH-2. This enhanced susceptibility of the female mice as compared to the male littermates appeared to be due to a decreased resistance to nocardial infections in the brains of the female animals. These data indicate that antibody and certain B-lymphocyte subpopulations are not essential components in host resistance to N. asteroides GUH-2 in these mice.

Full text

PDF

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Beaman B. L., Gershwin M. E., Maslan S. Infectious agents in immunodeficient murine models: pathogenicity of Nocardia asteroides in congenitally athymic (nude) and hereditarily asplenic (Dh/+) mice. Infect Immun. 1978 May;20(2):381–387. doi: 10.1128/iai.20.2.381-387.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Beaman B. L., Gershwin M. E., Scates S. S., Ohsugi Y. Immunobiology of germfree mice infected with Nocardia asteroides. Infect Immun. 1980 Aug;29(2):733–743. doi: 10.1128/iai.29.2.733-743.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Beaman B. L., Goldstein E., Gershwin M. E., Maslan S., Lippert W. Lung response to congenitally athymic (nude), heterozygous, and Swiss Webster mice to aerogenic and intranasal infection by Nocardia asteroides. Infect Immun. 1978 Dec;22(3):867–877. doi: 10.1128/iai.22.3.867-877.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Beaman B. L. Interaction of Nocardia asteroides at different phases of growth with in vitro-maintained macrophages obtained from the lungs of normal and immunized rabbits. Infect Immun. 1979 Oct;26(1):355–361. doi: 10.1128/iai.26.1.355-361.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Beaman B. L., Maslan S. Effect of cyclophosphamide on experimental Nocardia asteroides infection in mice. Infect Immun. 1977 Jun;16(3):995–1004. doi: 10.1128/iai.16.3.995-1004.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Beaman B. L., Maslan S., Scates S., Rosen J. Effect of route on inoculation on host resistance to Nocardia. Infect Immun. 1980 Apr;28(1):185–189. doi: 10.1128/iai.28.1.185-189.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Beaman B. L., Maslan S. Virulence of Nocardia asteroides during its growth cycle. Infect Immun. 1978 Apr;20(1):290–295. doi: 10.1128/iai.20.1.290-295.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Brown A. R., Crandall C. A., Crandall R. B. The immune response and acquired resistance to Ascaris suum infection in mice with an X-linked B lymphocyte defect. J Parasitol. 1977 Oct;63(5):950–952. [PubMed] [Google Scholar]
  9. Davis-Scibienski C., Beaman B. L. Interaction of alveolar macrophages with Nocardia asteroides: immunological enhancement of phagocytosis, phagosome-lysosome fusion, and microbicidal activity. Infect Immun. 1980 Nov;30(2):578–587. doi: 10.1128/iai.30.2.578-587.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Fidler J. M., Morgan E. L., Weigle W. O. B lymphocyte differentiation in the CBA/N mouse: a delay in maturation rather than a total arrest. J Immunol. 1980 Jan;124(1):13–19. [PubMed] [Google Scholar]
  11. Filice G. A., Beaman B. L., Krick J. A., Remington J. S. Effects of human neutrophils and monocytes on Nocardia asteroides: failure of killing despite occurrence of the oxidative metabolic burst. J Infect Dis. 1980 Sep;142(3):432–438. doi: 10.1093/infdis/142.3.432. [DOI] [PubMed] [Google Scholar]
  12. Filice G. A., Beaman B. L., Remington J. S. Effects of activated macrophages on Nacardia asteroides. Infect Immun. 1980 Feb;27(2):643–649. doi: 10.1128/iai.27.2.643-649.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Hunter K. W., Jr, Finkelman F. D., Strickland G. T., Sayles P. C., Scher I. Defective resistance to Plasmodium yoelii in CBA/N mice. J Immunol. 1979 Jul;123(1):133–137. [PubMed] [Google Scholar]
  14. Jayawardena A. N., Janeway C. A., Jr, Kemp J. D. Experimental malaria in the CBA/N mouse. J Immunol. 1979 Dec;123(6):2532–2539. [PubMed] [Google Scholar]
  15. Krick J. A., Remington J. S. Resistance to infection with Nocardia asteroides. J Infect Dis. 1975 Jun;131(6):665–672. doi: 10.1093/infdis/131.6.665. [DOI] [PubMed] [Google Scholar]
  16. O'Brien A. D., Scher I., Campbell G. H., MacDermott R. P., Formal S. B. Susceptibility of CBA/N mice to infection with Salmonella typhimurium: influence of the X-linked gene controlling B lymphocyte function. J Immunol. 1979 Aug;123(2):720–724. [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES