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. 1982 Jan;35(1):222–228. doi: 10.1128/iai.35.1.222-228.1982

Effects of compromising agents on candidosis in mice with persistent infections initiated in infancy.

M N Guentzel, C Herrera
PMCID: PMC351019  PMID: 7033136

Abstract

Oral-intragastric inoculation of infant CFW mice with Candida albicans, leading either to lethality or to persistent infection of long duration, provides a useful model for study of the host-pathogen interrelationships in candidosis. Mice were most susceptible to the lethal effects of challenge when 4 to 6 days of age, increasingly resistant up to 10 to 11 days, and then resistant to doses of C. albicans lethal for the younger animals. Older mice harboring persistent infections of the gastrointestinal tract, originally initiated when the animals were 6 days old, were used to study the effects of agents which commonly are administered to cancer patients or which are known to predispose to candidosis. The broad-spectrum antibiotic chloramphenicol, cortisone acetate, X-irradiation, or single high doses of cyclophosphamide (Cytoxan) resulted in markedly enhanced levels of C. albicans in the gastrointestinal tract without systemic spread. Repeated smaller doses of Cytoxan, or treatment with methotrexate or a combination of cortisone acetate and Cytoxan, produced gastrointestinal candidosis associated with invasion and systemic spread. The data indicate that the persistently infected animals provide a realistic model for studying treatments that precipitate candidosis in humans.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Cho S. Y., Choi H. Y. Opportunistic fungal infection among cancer patients. A ten-year autopsy study. Am J Clin Pathol. 1979 Oct;72(4):617–621. doi: 10.1093/ajcp/72.4.617. [DOI] [PubMed] [Google Scholar]
  2. Eras P., Goldstein M. J., Sherlock P. Candida infection of the gastrointestinal tract. Medicine (Baltimore) 1972 Sep;51(5):367–379. doi: 10.1097/00005792-197209000-00002. [DOI] [PubMed] [Google Scholar]
  3. Evans E. G. The incidence of pathogenic yeasts among open-heart surgery patients-the value of prophylaxis. J Thorac Cardiovasc Surg. 1975 Sep;70(3):466–470. [PubMed] [Google Scholar]
  4. Field L. H., Pope L. M., Cole G. T., Guentzel M. N., Berry L. J. Persistence and spread of Candida albicans after intragastric inoculation of infant mice. Infect Immun. 1981 Feb;31(2):783–791. doi: 10.1128/iai.31.2.783-791.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Gaines J. D., Remington J. S. Disseminated candidiasis in the surgical patient. Surgery. 1972 Nov;72(5):730–736. [PubMed] [Google Scholar]
  6. Guentzel M. N., Berry L. J. Protection of suckling mice from experimental cholera by maternal immunization: comparison of the efficacy of whole-cell, ribosomal-derived, and enterotoxin immunogens. Infect Immun. 1974 Jul;10(1):167–172. doi: 10.1128/iai.10.1.167-172.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Krause W., Matheis H., Wulf K. Fungaemia and funguria after oral administration of Candida albicans. Lancet. 1969 Mar 22;1(7595):598–599. doi: 10.1016/s0140-6736(69)91534-7. [DOI] [PubMed] [Google Scholar]
  8. Montgomerie J. Z., Edwards J. E., Jr Association of infection due to Candida albicans with intravenous hyperalimentation. J Infect Dis. 1978 Feb;137(2):197–201. doi: 10.1093/infdis/137.2.197. [DOI] [PubMed] [Google Scholar]
  9. Myerowitz R. L. Gastrointestinal and disseminated candidiasis. An experimental model in the immunosuppressed rat. Arch Pathol Lab Med. 1981 Mar;105(3):138–143. [PubMed] [Google Scholar]
  10. Myerowitz R. L., Pazin G. J., Allen C. M. Disseminated candidiasis. Changes in incidence, underlying diseases, and pathology. Am J Clin Pathol. 1977 Jul;68(1):29–38. doi: 10.1093/ajcp/68.1.29. [DOI] [PubMed] [Google Scholar]
  11. Parker J. C., Jr, McCloskey J. J., Lee R. S. The emergence of candidosis. The dominant postmortem cerebral mycosis. Am J Clin Pathol. 1978 Jul;70(1):31–36. doi: 10.1093/ajcp/70.1.31. [DOI] [PubMed] [Google Scholar]
  12. Pope L. M., Cole G. T., Guentzel M. N., Berry L. J. Systemic and gastrointestinal candidiasis of infant mice after intragastric challenge. Infect Immun. 1979 Aug;25(2):702–707. doi: 10.1128/iai.25.2.702-707.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Ray T. L. Fungal infections in the immunocompromised host. Med Clin North Am. 1980 Sep;64(5):955–968. doi: 10.1016/s0025-7125(16)31576-0. [DOI] [PubMed] [Google Scholar]
  14. Remington J. S., Anderson S. E., Jr Pneumocystis and fungal infection in patients with malignancies. Int J Radiat Oncol Biol Phys. 1976 Jan-Feb;1(3-4):313–315. doi: 10.1016/0360-3016(76)90059-6. [DOI] [PubMed] [Google Scholar]
  15. Stone H. H., Kolb L. D., Currie C. A., Geheber C. E., Cuzzell J. Z. Candida sepsis: pathogenesis and principles of treatments. Ann Surg. 1974 May;179(5):697–711. doi: 10.1097/00000658-197405000-00024. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Umenai T., Konno S., Yamauchi A., Iimura Y., Fujimoto H. Growth of Candida in the upper intestinal tract as a possible source of systemic candidiasis in mice. Tohoku J Exp Med. 1980 Jan;130(1):101–102. doi: 10.1620/tjem.130.101. [DOI] [PubMed] [Google Scholar]
  17. Volkheimer G., Schulz F. H., Aurich I., Strauch S., Beuthin K., Wendlandt H. Persorption of particles. Digestion. 1968;1(2):78–80. doi: 10.1159/000196836. [DOI] [PubMed] [Google Scholar]
  18. Wingard J. R., Dick J. D., Merz W. G., Sandford G. R., Saral R., Burns W. H. Pathogenicity of Candida tropicalis and Candida albicans after gastrointestinal inoculation in mice. Infect Immun. 1980 Aug;29(2):808–813. doi: 10.1128/iai.29.2.808-813.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]

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