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. 1982 Jan;35(1):320–325. doi: 10.1128/iai.35.1.320-325.1982

Effect of nitrogen mustard on natural history of right-sided streptococcal endocarditis in rabbits: role for cellular host defenses.

B R Yersin, M P Glauser, L R Freedman
PMCID: PMC351032  PMID: 7054124

Abstract

Cellular host defenses are considered to be ineffective in bacterial endocarditis; the microorganisms in infected vegetations are protected from phagocytic cells by dense layers of fibrin. To test this hypothesis, nitrogen mustard-induced agranulocytosis and leukopenia were produced in rabbits with right-sided streptococcal endocarditis. The spontaneous sterilization of tricuspid infection observed in the control animals was not present in the granulocytopenic, leukopenic animals. Since the bacterium Streptococcus intermedius is not sensitive to the complement-mediated bactericidal effect of serum and since the animals were not bacteremic during the time of agranulocytosis, an inhibitory effect of the drug on local cellular host defense mechanisms is postulated. We suggest that the spontaneous sterilization of infective endocarditis in the right side of the heart in rabbits is mediated by cellular host defenses.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abrams B., Sklaver A., Hoffman T., Greenman R. Single or combination therapy of staphylococcal endocarditis in intravenous drug abusers. Ann Intern Med. 1979 May;90(5):789–791. doi: 10.7326/0003-4819-90-5-789. [DOI] [PubMed] [Google Scholar]
  2. Archer G., Fekety F. R. Experimental endocarditis due to Pseudomonas aeruginosa. I. Description of a model. J Infect Dis. 1976 Jul;134(1):1–7. doi: 10.1093/infdis/134.1.1. [DOI] [PubMed] [Google Scholar]
  3. Durack D. T., Beeson P. B. Experimental bacterial endocarditis. I. Colonization of a sterile vegetation. Br J Exp Pathol. 1972 Feb;53(1):44–49. [PMC free article] [PubMed] [Google Scholar]
  4. Durack D. T., Beeson P. B. Experimental bacterial endocarditis. II. Survival of a bacteria in endocardial vegetations. Br J Exp Pathol. 1972 Feb;53(1):50–53. [PMC free article] [PubMed] [Google Scholar]
  5. Durack D. T., Beeson P. B., Petersdorf R. G. Experimental bacterial endocarditis. 3. Production and progress of the disease in rabbits. Br J Exp Pathol. 1973 Apr;54(2):142–151. [PMC free article] [PubMed] [Google Scholar]
  6. Durack D. T., Beeson P. B. Protective role of complement in experimental Escherichia coli endocarditis. Infect Immun. 1977 Apr;16(1):213–217. doi: 10.1128/iai.16.1.213-217.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Durack D. T. Experimental bacterial endocarditis. IV. Structure and evolution of very early lesions. J Pathol. 1975 Feb;115(2):81–89. doi: 10.1002/path.1711150204. [DOI] [PubMed] [Google Scholar]
  8. Francioli P. B., Freedman L. R. Streptococcal infection of endocardial and other intravascular vegetations in rabbits: natural history and effect of dexamethasone. Infect Immun. 1979 May;24(2):483–491. doi: 10.1128/iai.24.2.483-491.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Garrison P. K., Freedman L. R. Experimental endocarditis I. Staphylococcal endocarditis in rabbits resulting from placement of a polyethylene catheter in the right side of the heart. Yale J Biol Med. 1970 Jun;42(6):394–410. [PMC free article] [PubMed] [Google Scholar]
  10. Guze L. B., Hubert E. G., Kalmanson G. M. Pyelonephritis XI. Effect of Growth Phase of Streptococcus faecalis on Serum Susceptibility and Virulence. Infect Immun. 1970 Jun;1(6):532–537. doi: 10.1128/iai.1.6.532-537.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. HIRSCH J. G. Comparative bactericidal activities of blood serum and plasma serum. J Exp Med. 1960 Jul 1;112:15–22. doi: 10.1084/jem.112.1.15. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Kaspar R. L., Drutz D. J. Perihepatitis and hepatitis as complications of experimental endocarditis due to Neisseria gonorrhoeae in the rabbit. J Infect Dis. 1977 Jul;136(1):37–42. doi: 10.1093/infdis/136.1.37. [DOI] [PubMed] [Google Scholar]
  13. Lorian V., Atkinson B. Effect of serum on gram-positive cocci grown in the presence of penicillin. J Infect Dis. 1978 Dec;138(6):865–871. doi: 10.1093/infdis/138.6.865. [DOI] [PubMed] [Google Scholar]
  14. Perlman B. B., Freedman L. R. Experimental endocarditis. 3. Natural history of catheter induced staphylococcal endocarditis following catheter removal. Yale J Biol Med. 1971 Oct;44(2):214–224. [PMC free article] [PubMed] [Google Scholar]
  15. Phair J. P., Clarke J. Immunology of infective endocarditis. Prog Cardiovasc Dis. 1979 Nov-Dec;22(3):137–144. doi: 10.1016/0033-0620(79)90019-7. [DOI] [PubMed] [Google Scholar]
  16. Roberts W. C., Buchbinder N. A. Right-sided valvular infective endocarditis. A clinicopathologic study of twelve necropsy patients. Am J Med. 1972 Jul;53(1):7–19. doi: 10.1016/0002-9343(72)90111-8. [DOI] [PubMed] [Google Scholar]

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