Abstract
Mouse peritoneal macrophages were successfully infected with two strains of Junin virus producing high titers with no apparent cell damage. Infected cultures survived longer than noninfected cultures. The pattern of virus release suggested a persistent infection. Virus replication was delayed in macrophages from mice previously immunized with Junin virus. These results support the opinion that macrophages are targets for virus replication in vivo infections.
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- Carballal G., Cossio P. M., Laguens R. P., Ponzinibbio C., Oubiña J. R., Meckert P. C., Rabinovich A., Arana R. M. Junin virus infection of guinea pigs: immunohistochemical and ultrastructural studies of hemopoietic tissue. J Infect Dis. 1981 Jan;143(1):7–14. doi: 10.1093/infdis/143.1.7. [DOI] [PubMed] [Google Scholar]
- Coto C. E., Damonte E. B., Catello M. A., Weissenbacher M. C. Protection of guinea pigs inoculated with Tacaribe virus against lethal doses of Junin virus. J Infect Dis. 1980 Mar;141(3):389–393. doi: 10.1093/infdis/141.3.389. [DOI] [PubMed] [Google Scholar]
- Damonte E. B., Coto C. E. Temperature sensitivity of the arenavirus junin isolated from persistently infected Vero cells. Intervirology. 1979;11(5):282–287. doi: 10.1159/000149046. [DOI] [PubMed] [Google Scholar]
- Doyle M. V., Oldstone M. B. Interactions between viruses and lymphocytes. I. In vivo replication of lymphocytic choriomeningitis virus in mononuclear cells during both chronic and acute viral infections. J Immunol. 1978 Oct;121(4):1262–1269. [PubMed] [Google Scholar]
- González P. H., Cossio P. M., Arana R., Maiztegui J. I., Laguens R. P. Lymphatic tissue in Argentine hemorrhagic fever. Pathologic features. Arch Pathol Lab Med. 1980 May;104(5):250–254. [PubMed] [Google Scholar]
- Popescu M., Löhler J., Lehmann-Grube F. Infectious lymphocytes in lymphocytic choriomeningitis virus carrier mice. J Gen Virol. 1979 Mar;42(3):481–492. doi: 10.1099/0022-1317-42-3-481. [DOI] [PubMed] [Google Scholar]
- Schwartz R., Löhler J., Lehmann-Grube F. Infection of cultivated mouse peritoneal macrophages with lymphocytic choriomeningitis virus. J Gen Virol. 1978 Jun;39(3):565–570. doi: 10.1099/0022-1317-39-3-565. [DOI] [PubMed] [Google Scholar]
- Vidal M. C., Coto C. E. Infección persistente de células de ratón con virus Junin: participación del interferón. Medicina (B Aires) 1980 Sep-Oct;40(5):537–542. [PubMed] [Google Scholar]