Abstract
We prepared antitoxins specific for each of two toxins of Clostridium difficile and used these to demonstrate that the toxins are immunologically distinct.
Full text
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Abrams G. D., Allo M., Rifkin G. D., Fekety R., Silva J., Jr Mucosal damage mediated by clostridial toxin in experimental clindamycin-associated colitis. Gut. 1980 Jun;21(6):493–499. doi: 10.1136/gut.21.6.493. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Allo M., Silva J., Jr, Fekety R., Rifkin G. D., Waskin H. Prevention of clindamycin-induced colitis in hamsters by Clostridium sordellii antitoxin. Gastroenterology. 1979 Feb;76(2):351–355. [PubMed] [Google Scholar]
- Bartlett J. G., Chang T., Taylor N. S., Onderdonk A. B. Colitis induced by Clostridium difficile. Rev Infect Dis. 1979 Mar-Apr;1(2):370–378. doi: 10.1093/clinids/1.2.370. [DOI] [PubMed] [Google Scholar]
- Bartlett J. G., Onderdonk A. B., Cisneros R. L., Kasper D. L. Clindamycin-associated colitis due to a toxin-producing species of Clostridium in hamsters. J Infect Dis. 1977 Nov;136(5):701–705. doi: 10.1093/infdis/136.5.701. [DOI] [PubMed] [Google Scholar]
- Bartlett J. G., Taylor N. S., Chang T., Dzink J. Clinical and laboratory observations in Clostridium difficile colitis. Am J Clin Nutr. 1980 Nov;33(11 Suppl):2521–2526. doi: 10.1093/ajcn/33.11.2521. [DOI] [PubMed] [Google Scholar]
- Chang T. W., Bartlett J. G., Gorbach S. L., Onderdonk A. B. Clindamycin-induced enterocolitis in hamsters as a model of pseudomembranous colitis in patients. Infect Immun. 1978 May;20(2):526–529. doi: 10.1128/iai.20.2.526-529.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Donta S. T., Shaffer S. J. Effects of Clostridium difficile toxin on tissue-cultured cells. J Infect Dis. 1980 Feb;141(2):218–222. doi: 10.1093/infdis/141.2.218. [DOI] [PubMed] [Google Scholar]
- Ehrich M., Van Tassell R. L., Libby J. M., Wilkins T. D. Production of Clostridium difficile antitoxin. Infect Immun. 1980 Jun;28(3):1041–1043. doi: 10.1128/iai.28.3.1041-1043.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
- George W. L., Rolfe R. D., Sutter V. L., Finegold S. M. Diarrhea and colitis associated with antimicrobial therapy in man and animals. Am J Clin Nutr. 1979 Jan;32(1):251–257. doi: 10.1093/ajcn/32.1.251. [DOI] [PubMed] [Google Scholar]
- George W. L., Rolfe R. D., Sutter V. L., Finegold S. M. Diarrhea and colitis associated with antimicrobial therapy in man and animals. Am J Clin Nutr. 1979 Jan;32(1):251–257. doi: 10.1093/ajcn/32.1.251. [DOI] [PubMed] [Google Scholar]
- Kim K. H., Fekety R., Batts D. H., Brown D., Cudmore M., Silva J., Jr, Waters D. Isolation of Clostridium difficile from the environment and contacts of patients with antibiotic-associated colitis. J Infect Dis. 1981 Jan;143(1):42–50. doi: 10.1093/infdis/143.1.42. [DOI] [PubMed] [Google Scholar]
- Larson H. E., Price A. B., Borriello S. P. Epidemiology of experimental enterocecitis due to Clostridium difficile. J Infect Dis. 1980 Sep;142(3):408–413. doi: 10.1093/infdis/142.3.408. [DOI] [PubMed] [Google Scholar]
- Rolfe R. D., Finegold S. M. Purification and characterization of Clostridium difficile toxin. Infect Immun. 1979 Jul;25(1):191–201. doi: 10.1128/iai.25.1.191-201.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Taylor N. S., Bartlett J. G. Partial purification and characterization of a cytotoxin from Clostridium difficile. Rev Infect Dis. 1979 Mar-Apr;1(2):379–385. doi: 10.1093/clinids/1.2.379. [DOI] [PubMed] [Google Scholar]