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. 1982 Feb;35(2):600–604. doi: 10.1128/iai.35.2.600-604.1982

Human leukocyte antigen-linked genetic controls for T cell-mediated cytotoxic response to mumps virus in humans.

Y Chiba, H Tsutsumi, T Nakao, A Wakisaka, M Aizawa
PMCID: PMC351083  PMID: 6976937

Abstract

The involvement of human leukocyte antigen determinants for the response of mumps virus-specific cytotoxic T lymphocytes in humans was studied. The cytotoxic T lymphocytes could only lyse virus-infected allogeneic cells with which they shared a particular human leukocyte antigen, e.g., Bw52 or B7. The existence of Bw52 in the subjects who received a booster immunization with live mumps vaccine was associated with a significantly higher cytotoxic T-lymphocyte response than that of subjects without the gene. Although a donor-dependent difference in the recognition of human leukocyte antigen-A2 suggests the complexity of the genetic mechanisms involved, the results are largely consistent with the concept of major histocompatibility complex-linked genetic control of virus-specific cytotoxic T-lymphocyte response.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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