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. 1982 Feb;35(2):738–740. doi: 10.1128/iai.35.2.738-740.1982

Non-immunoglobulin fraction of human milk protects rabbits against enterotoxin-induced intestinal fluid secretion.

A B Otnaess, A M Svennerholm
PMCID: PMC351104  PMID: 7056585

Abstract

Human milk was fractionated by ammonium sulphate precipitation and column chromatography. A milk fraction depleted of secretory immunoglobulin A and with an apparent molecular weight of greater than 400,000 inhibited fluid secretion induced by cholera toxin and Escherichia coli heat-labile toxin in rabbit ileal loops.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Donta S. T., Sack D. A., Wallace R. B., Dupont H. L., Sack R. B. Tissue-culture assay of antibodies to heat-liable Escherichia coli enterotoxins. N Engl J Med. 1974 Jul 18;291(3):117–121. doi: 10.1056/NEJM197407182910302. [DOI] [PubMed] [Google Scholar]
  2. Gerrard J. W. Breast-feeding: second thoughts. Pediatrics. 1974 Dec;54(6):757–764. [PubMed] [Google Scholar]
  3. Goldman A. S., Smith C. W. Host resistance factors in human milk. J Pediatr. 1973 Jun;82(6):1082–1090. doi: 10.1016/s0022-3476(73)80453-6. [DOI] [PubMed] [Google Scholar]
  4. Otnaess A. B., Halvorsen S. Non-antibody components in human milk inhibit Escherichia coli heat labile enterotoxin measured by an enzyme-linked immunosorbent assay. Acta Pathol Microbiol Scand C. 1980 Oct;88(5):247–253. doi: 10.1111/j.1699-0463.1980.tb00102.x. [DOI] [PubMed] [Google Scholar]
  5. Otnaess A. B., Orstavik I. Effect of fractions of Ethiopian And Norwegian colostrum on rotavirus and Escherichia coli heat-labile enterotoxin. Infect Immun. 1981 Aug;33(2):459–466. doi: 10.1128/iai.33.2.459-466.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Otnaess A. B., Orstavik I. The effect of human milk fractions on rotavirus in relation to the secretory IgA content. Acta Pathol Microbiol Scand C. 1980 Feb;88(1):15–21. doi: 10.1111/j.1699-0463.1980.tb00067.x. [DOI] [PubMed] [Google Scholar]
  7. Sack R. B. Human diarrheal disease caused by enterotoxigenic Escherichia coli. Annu Rev Microbiol. 1975;29:333–353. doi: 10.1146/annurev.mi.29.100175.002001. [DOI] [PubMed] [Google Scholar]
  8. Svennerholm A. M. Experimental studies on cholera immunization. 4. The antibody response to formalinized Vibrio cholerae and purified endotoxin with special reference to protective capacity. Int Arch Allergy Appl Immunol. 1975;49(4):434–452. [PubMed] [Google Scholar]

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