Abstract
High levels of natural killer (NK) cell activity and high titers of interferon were observed in the peritoneal exudate of C57BL/6 mice 20 to 50 h after injection of mouse hepatitis virus type 3 (MHV3) but not during the first 10 h after infection. C57BL/6 mice were susceptible to MHV3 infection and showed high titers of MHV3 in the peritoneal exudate 48 h after infection. A/J mice, in contrast, were resistant to the dose that killed 100% of the C57BL/6 mice (10 macrophage-infecting doses) and showed considerably lower virus titers than those shown by C57BL/6 mice. NK cell activity and interferon titers were significantly lower in the peritoneal exudate of A/J mice than in that of C57BL/6 mice. Serum interferon titers were also lower in A/J mice. Thus, our data show an inverse relationship between resistance and the levels of these two parameters. The data suggest that, in contrast to the situation observed with certain herpesviruses, interferon and NK cells may not be of overwhelming importance in the defense of mice against MHV3.
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- Armerding D., Rossiter H. Induction of natural killer cells by herpes-simplex virus type 2 in resistant and sensitive inbred mouse strains. Immunobiology. 1981;158(4):369–379. doi: 10.1016/S0171-2985(81)80007-1. [DOI] [PubMed] [Google Scholar]
- Bancroft G. J., Shellam G. R., Chalmer J. E. Genetic influences on the augmentation of natural killer (NK) cells during murine cytomegalovirus infection: correlation with patterns of resistance. J Immunol. 1981 Mar;126(3):988–994. [PubMed] [Google Scholar]
- Bang F. B., Warwick A. MOUSE MACROPHAGES AS HOST CELLS FOR THE MOUSE HEPATITIS VIRUS AND THE GENETIC BASIS OF THEIR SUSCEPTIBILITY. Proc Natl Acad Sci U S A. 1960 Aug;46(8):1065–1075. doi: 10.1073/pnas.46.8.1065. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Engler H., Zawatzky R., Goldbach A., Schröder C. H., Weyand C., Hämmerling G. J., Kirchner H. Experimental infection of inbred mice with herpes simplex virus. II. Interferon production and activation of natural killer cells in the peritoneal exudate. J Gen Virol. 1981 Jul;55(Pt 1):25–30. doi: 10.1099/0022-1317-55-1-25. [DOI] [PubMed] [Google Scholar]
- Hirsch R. L. Natural killer cells appear to play no role in the recovery of mice from Sindbis virus infection. Immunology. 1981 May;43(1):81–89. [PMC free article] [PubMed] [Google Scholar]
- Klimetzek V., Remold H. G. The murine bone marrow macrophage, a sensitive indicator cell for murine migration inhibitory factor and a new method for their harvest. Cell Immunol. 1980 Aug 1;53(2):257–266. doi: 10.1016/0008-8749(80)90327-5. [DOI] [PubMed] [Google Scholar]
- Lopez C. Genetics of natural resistance to herpesvirus infections in mice. Nature. 1975 Nov 13;258(5531):152–153. doi: 10.1038/258152a0. [DOI] [PubMed] [Google Scholar]
- Schindler L., Streissle G., Kirchner H. Protection of mice against mouse hepatitis virus by Corynebacterium parvum. Infect Immun. 1981 Jun;32(3):1128–1131. doi: 10.1128/iai.32.3.1128-1131.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Tardieu M., Héry C., Dupuy J. M. Neonatal susceptibility to MHV3 infection in mice. II. Role of natural effector marrow cells in transfer of resistance. J Immunol. 1980 Jan;124(1):418–423. [PubMed] [Google Scholar]
- Virelizier J. L., Gresser I. Role of interferon in the pathogenesis of viral diseases of mice as demonstrated by the use of anti-interferon serum. V. Protective role in mouse hepatitis virus type 3 infection of susceptible and resistant strains of mice. J Immunol. 1978 May;120(5):1616–1619. [PubMed] [Google Scholar]
- Welsh R. M., Jr, Kiessling R. W. Natural killer cell response to lymphocytic choriomeningitis virus in beige mice. Scand J Immunol. 1980;11(4):363–367. doi: 10.1111/j.1365-3083.1980.tb00001.x. [DOI] [PubMed] [Google Scholar]
- Zawatzky R., Hilfenhaus J., Marcucci F., Kirchner H. Experimental infection of inbred mice with herpes simplex virus type 1. I. Investigation of humoral and cellular immunity and of interferon induction. J Gen Virol. 1981 Mar;53(Pt 1):31–38. doi: 10.1099/0022-1317-53-1-31. [DOI] [PubMed] [Google Scholar]