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. 1982 Apr;36(1):184–188. doi: 10.1128/iai.36.1.184-188.1982

Protection of mice from infection with Streptococcus pneumoniae by anti-phosphocholine antibody.

J Yother, C Forman, B M Gray, D E Briles
PMCID: PMC351201  PMID: 7076292

Abstract

Anti-phosphocholine (PC) antibody mediated protection against many strains of Streptococcus pneumoniae, and hybridoma anti-PC antibodies protected mice from fatal infections with types 1 and 3 S. pneumoniae. Live types 1, 3, 5, 6A, and 19F S. pneumoniae had similar amounts of surface PC accessible to antibody. Furthermore, mice expressing the X-linked immunodeficiency (xid) of the CBA/N strain were found to be more susceptible to infection with S. pneumoniae of types 3, 6A, and 19F than were immunologically normal mice. The only exception to these results was with the type 5 strain, which was highly virulent for both xid and normal mice. In addition, we were unable to protect mice against infection with the type 5 strain by using anti-PC antibody.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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