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In vitro data supports a direct role of leptin on bone cells. Two opposing bodies of literature: (A) Under normal serum conditions, leptin induces proliferation of osteoblasts and suppression of adipocyte differentiation. Additional evidence demonstrates that leptin suppresses osteoclast recruitment by enhancing osteoblast OPG expression. (B) Under low serum conditions, leptin has either no effect on osteoblast differentiation, or induces apoptosis of osteoblast precursors.
