Skip to main content
PMC home page
Infection and Immunity logoLink to Infection and Immunity
. 1982 Apr;36(1):284–288. doi: 10.1128/iai.36.1.284-288.1982

Interferon independence of genetically controlled resistance to flaviviruses.

M A Brinton, H Arnheiter, O Haller
PMCID: PMC351216  PMID: 6176543

Abstract

Flavivirus-resistant C3H/RV mice injected with sheep anti-interferon globulin and then infected with either West Nile or yellow fever virus survived and displayed no disease symptoms. Also, treatment of embryo fibroblast cultures prepared from C3H/RV or congenic susceptible C3H/HE mice with anti-interferon serum resulted in an increased yield of West Nile virus from both types of cultures, but the amount of infectious virus produced by resistant cultures remained 1 to 1.5 logs lower than that produced by susceptible cell cultures. These results indicate that the mode of expression of the flavivirus resistance gene differs significantly from that of the Mx gene conferring resistance to influenza virus-induced disease in A2G mice.

Full text

PDF
284

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Arnheiter H., Haller O., Lindenmann J. Host gene influence on interferon action in adult mouse hepatocytes: specificity for influenza virus. Virology. 1980 May;103(1):11–20. doi: 10.1016/0042-6822(80)90122-1. [DOI] [PubMed] [Google Scholar]
  2. Bang F. B. Genetics of resistance of animals to viruses: I. Introduction and studies in mice. Adv Virus Res. 1978;23:269–348. doi: 10.1016/S0065-3527(08)60102-5. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Brinton M. A. Isolation of a replication-efficient mutant of West Nile virus from a persistently infected genetically resistant mouse cell culture. J Virol. 1981 Aug;39(2):413–421. doi: 10.1128/jvi.39.2.413-421.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Brinton M. A., Nathanson N. Genetic determinants of virus susceptibility: epidemiologic implications of murine models. Epidemiol Rev. 1981;3:115–139. doi: 10.1093/oxfordjournals.epirev.a036230. [DOI] [PubMed] [Google Scholar]
  5. Darnell M. B., Koprowski H. Genetically determined resistance to infection with group B arboviruses. II. Increased production of interfering particles in cell cultures from resistant mice. J Infect Dis. 1974 Mar;129(3):248–256. doi: 10.1093/infdis/129.3.248. [DOI] [PubMed] [Google Scholar]
  6. Darnell M. B., Koprowski H., Lagerspetz K. Genetically determined resistance to infection with group B arboviruses. I. Distribution of the resistance gene among various mouse populations and characteristics of gene expression in vivo. J Infect Dis. 1974 Mar;129(3):240–247. doi: 10.1093/infdis/129.3.240. [DOI] [PubMed] [Google Scholar]
  7. GOODMAN G. T., KOPROWSKI H. Study of the mechanism of innate resistance to virus infection. J Cell Comp Physiol. 1962 Jun;59:333–373. doi: 10.1002/jcp.1030590313. [DOI] [PubMed] [Google Scholar]
  8. Gresser I., Tovey M. G., Bandu M. E., Maury C., Brouty-Boyé D. Role of interferon in the pathogenesis of virus diseases in mice as demonstrated by the use of anti-interferon serum. I. Rapid evolution of encephalomyocarditis virus infection. J Exp Med. 1976 Nov 2;144(5):1305–1315. doi: 10.1084/jem.144.5.1305. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Gröschel D., Koprowski H. Development of a virus-resistant inbred mouse strain for the study of innate resistance to Arbo B viruses. Arch Gesamte Virusforsch. 1965;17(3):379–391. doi: 10.1007/BF01241192. [DOI] [PubMed] [Google Scholar]
  10. Haller O., Arnheiter H., Gresser I., Lindenmann J. Genetically determined, interferon-dependent resistance to influenza virus in mice. J Exp Med. 1979 Mar 1;149(3):601–612. doi: 10.1084/jem.149.3.601. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Haller O., Arnheiter H., Lindenmann J., Gresser I. Host gene influences sensitivity to interferon action selectively for influenza virus. Nature. 1980 Feb 14;283(5748):660–662. doi: 10.1038/283660a0. [DOI] [PubMed] [Google Scholar]
  12. LINDENMANN J., LANE C. A., HOBSON D. THE RESISTANCE OF A2G MICE TO MYXOVIRUSES. J Immunol. 1963 Jun;90:942–951. [PubMed] [Google Scholar]
  13. Lynch C. J., Hughes T. P. The Inheritance of Susceptibility to Yellow Fever Encephalitis in Mice. Genetics. 1936 Mar;21(2):104–112. doi: 10.1093/genetics/21.2.104. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Sabin A. B. Nature of Inherited Resistance to Viruses Affecting the Nervous System. Proc Natl Acad Sci U S A. 1952 Jun;38(6):540–546. doi: 10.1073/pnas.38.6.540. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Vaheri A., Sedwick W. D., Plotkin S. A., Maes R. Cytopathic effect of rubella virus in RHK21 cells and growth to high titers in suspension culture. Virology. 1965 Oct;27(2):239–241. doi: 10.1016/0042-6822(65)90170-4. [DOI] [PubMed] [Google Scholar]
  16. Virelizier J. L., Gresser I. Role of interferon in the pathogenesis of viral diseases of mice as demonstrated by the use of anti-interferon serum. V. Protective role in mouse hepatitis virus type 3 infection of susceptible and resistant strains of mice. J Immunol. 1978 May;120(5):1616–1619. [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES