Shaping the landscape: mechanistic consequences of ubiquitin modification of chromatin

Correction to: EMBO Rep (2012) 13, 619–630. doi:10.1038/embor.2012.78

In this article, published in the July issue of EMBO reports, the references in Table 1 were listed incorrectly. The corrected table has been reproduced here with the updated references. References 22 and 85 in the text were also incorrect; the corrected references are as follows: 22. Zofall M, Grewal SIS (2007) HULC, a histone H2B ubiquitinating complex, modulates heterochromatin independent of histone H3 lysine 4 methylation in fission yeast. J Biol Chem 282: 14065–14072; 85. Mamnun YM, Katayama S, Toda T (2006) Fission yeast Mcl1 interacts with SCF(Pof3) and is required for centromere formation. Biochem Biophys Res Commun 350: 125–130. The reference previously numbered as 85, on page 628 column 2 line 23, is now reference 86. We apologize for these errors.

Table 1. Roles of E3 ligases in chromatin.

E3	Species	Substrate	Process		Mode	Mechanism	Recruitment	References
Bre1	Sc Sp Dm Hs	H2B-K123	Txn initiation	E	Mono	Recruitment	HMTase	28,29
	Sc Hs	H2B-K123	Txn elongation	E	Mono	Decompact	FACT?	25,26,31
	Hs	H2B-K123	Txn repression	E	Mono	Competition	TFIIS	23
MSL2	Hs	H2B-134	Txn initiation	E	Mono	Recruitment?	HMTase? Bre1?	33
RING1B	Dm, Hs	H2A (H2A.Z)	Txn repression	H	Mono	Masking	HTMase, FACT	42,43
	Hs	H2A	Txn repression	H	Mono	Recruitment	PRC1	44
	Hs	H2A	Txn de-repress.	H	Mono	Recruitment	ZRF1	44
	Hs	H2A	Txn repression	H	Mono	Recruitment	RYBP?	46
2A-HUB	Hs	H2A	Txn repression	H	Mono	Masking	FACT	38
UBR2	Mm	H2A	Meiotic silenc.	H	Poly?	Masking?	FACT?	39
BRCA1	Hs	H2A	Txn repression	H	Mono	Masking?	FACT?	40
SCFPof1	Sp	Ams2	Histone levels	S	Poly	Degradation	Proteasome	49
Tom1	Sc	histones	Histone levels	S	Poly	Degradation	Proteasome	50
Psh1	Sc Sp Dm Hs	Cse4	Histone incorp.	E	Poly	Degradation	Proteasome	51, 52
SCFPpa	Ds, Hs	CID	Histone incorp.	E	Poly	Degradation	Proteasome	53
Cul4–Ddb1Cdt2	Hs	Set8/PR-Set7	Condensation	E	Poly	Degradation	Proteasome	57–61
SCFSkp2	Hs	MLL	Cell cycle	S	Poly	Degradation	Proteasome	62
APC/C	Hs	MLL	Cell cycle	S	Poly	Degradation	Proteasome	62
SCFFbx4	Hs	JMJD2A	Cell cycle	S	Poly	Degradation	Proteasome	63
Not4	Sc (Hs)	Jhd2 (JARID1C)	Txn	S	Poly	Degradation	Proteasome	64
Cul4–Ddb1Cdt2	Sp	Epe1	Boundary	H	?	?	?	65
Cul4–Rik1Raf1/2	Sp	?	H3K9me	H	?	?	?	66–70
Cul4–Ddb1DCAF26	Nc	?	H3K9me	H	?	?	?	71–74
Cul2/5–ELC	Cr	?	H3K9me	H	?	?	?	75
Cul4–Ddb1Msi1	At	?	H3K27me	H	?	?	?	76
Cul4–Ddb1EED	Hs	?	H3K27me	H	?	?	?	77
Msc1	Sp	?	HP1 dynamics	H	?	?	?	78–83
Cul8–Mms1Mms22	Sc	Ctf4?	Silencing	H	?	?	?	84
SCFPof3	Sp	Mcl1 (Ctf4)?	Silencing	H	?	?	?	85
APC/C	Sp	?	H3K9me	H	?	?	?	86

2A-HUB, 2A-histone ubiquitin ligase; APC/C, anaphase promoting complex/cyclosome; At, Arabidopsis thaliana; BRCA1, breast cancer 1; Bre1, brefeldin A sensitivity; Cr, Chlamydomonas reinhardtii; Ctf4, chromosome transmission fidelity; Cul2/4/5/8, Cullin 2/4/5/8; Ddb1, DNA damage-binding protein 1; de-repress., de-repression; Dm, Drosophila melanogaster; E, euchromatin; ELC, elongin E; Epe1, enhancer of position effect 1; H, heterochromatin; Hs, Homo sapiens; incorp., incorporation; Msc1, multi-copy suppressor of Chk1; MSL2, male-specific lethal; Mm, Mus musculus; Mms1, methyl methane sulfonate sensitivity 1; mono, monoubiquitylation; Nc, Neurospora crassa; Not4, negative on TATA; Psh1, Pob3/Spt16/histone associated protein; poly, polyubiquitylation; RING1B, really interesting new gene 1B; S, soluble; Sc, Saccharomyces cerevisiae; SCF, Skp1-Cullin-F-box; Sp, Schizosaccharomyces pombe; Tom1, temperature-dependent organization in mitotic nucleus 1; txn, transcription; UBR2, ubiquitin protein ligase E3 in component n-recognin 2.