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. 1982 May;36(2):662–666. doi: 10.1128/iai.36.2.662-666.1982

Specificity of a mycoplasma mitogen for lymphocytes from human and various animal hosts.

B C Cole, L R Washburn, G J Sullivan, J R Ward
PMCID: PMC351280  PMID: 6979514

Abstract

Spleen lymphocytes from Lewis and Buffalo rats and peripheral blood lymphocytes from 10 human donors exhibited high levels of transformation when exposed to Mycoplasma arthritidis supernatants. In contrast, spleen lymphocytes from rabbits and guinea pigs and peripheral blood lymphocytes from sheep and calves failed to transform when exposed to M. arthritidis supernatants. The lymphocytes from all hosts were transformed in the presence of phytohemagglutinin or concanavalin A or both Serological studies failed to provide evidence that the responding hosts were presensitized against M. arthritidis antigens.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aldridge K. E., Cole B. C., Ward J. R. Mycoplasma-dependent activation of normal lymphocytes: induction of a lymphocyte-mediated cytotoxicity for allogeneic and syngeneic mouse target cells. Infect Immun. 1977 Nov;18(2):377–385. doi: 10.1128/iai.18.2.377-385.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Böyum A. Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g. Scand J Clin Lab Invest Suppl. 1968;97:77–89. [PubMed] [Google Scholar]
  3. CHANOCK R. M., HAYFLICK L., BARILE M. F. Growth on artificial medium of an agent associated with atypical pneumonia and its identification as a PPLO. Proc Natl Acad Sci U S A. 1962 Jan 15;48:41–49. doi: 10.1073/pnas.48.1.41. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Cole B. C., Aldridge K. E., Sullivan G. J., Ward J. R. Mycoplasma-dependent activation of normal mouse lymphocytes: requirement for functional T lymphocytes in the cytotoxicity reaction mediated by Mycoplasma arthritidis. Infect Immun. 1980 Oct;30(1):90–98. doi: 10.1128/iai.30.1.90-98.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Cole B. C., Aldridge K. E., Ward J. R. Mycoplasma-dependent activation of normal lymphocytes: mitogenic potential of mycoplasmas for mouse lymphocytes. Infect Immun. 1977 Nov;18(2):393–399. doi: 10.1128/iai.18.2.393-399.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Cole B. C., Daynes R. A., Ward J. R. Mycoplasma-mediated activation of normal mouse lymphocytes: induction of cytotoxic lymphocytes and lymphocyte transformation by Mycoplasma arthritidis are under Ir gene control. J Immunol. 1981 Mar;126(3):922–927. [PubMed] [Google Scholar]
  7. Cole B. C., Daynes R. A., Ward J. R. Stimulation of mouse lymphocytes by a mitogen derived from Mycoplasma arthritidis. I. Transformation is associated with an H-2-linked gene that maps to the I-E/I-C subregion. J Immunol. 1981 Nov;127(5):1931–1936. [PubMed] [Google Scholar]
  8. Cole B. C., Griffiths M. M., Eichwald E. J., Ward J. R. New models of chronic synovitis in rabbits induced by mycoplasmas: microbiological, histopathological, and immunological observations on rabbits injected with Mycoplasma arthritidis and Mycoplasma pulmonis. Infect Immun. 1977 Apr;16(1):382–396. doi: 10.1128/iai.16.1.382-396.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Cole B. C., Overall J. C., Jr, Lombardi P. S., Glasgow L. A. Induction of interferon in ovine and human lymphocyte cultures by mycoplasmas. Infect Immun. 1976 Jul;14(1):88–94. doi: 10.1128/iai.14.1.88-94.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Cole B. C., Ward J. R., Jones R. S., Cahill J. F. Chronic proliferative arthritis of mice induced by Mycoplasma arthritidis. I. Induction of disease and histopathological characteristics. Infect Immun. 1971 Oct;4(4):344–355. doi: 10.1128/iai.4.4.344-355.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Golightly-Rowland L., Cole B. C., Ward J. R., Wiley B. B. Effect of Animal Passage on Arthritogenic and Biological Properties of Mycoplasma arthritidis. Infect Immun. 1970 Jun;1(6):538–545. doi: 10.1128/iai.1.6.538-545.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Horowitz S. A., Cassell G. H. Detection of antibodies to Mycoplasma pulmonis by an enzyme-linked immunosorbent assay. Infect Immun. 1978 Oct;22(1):161–170. doi: 10.1128/iai.22.1.161-170.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Sachs D. H., Humphrey G. W., Lunney J. K. Sharing of Ia antigens between species. I. Detection of Ia specificities shared by rats and mice. J Exp Med. 1977 Aug 1;146(2):381–393. doi: 10.1084/jem.146.2.381. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Silver J., Walker L. E., Reisfeld R. A., Pellegrino M. A., Ferrone S. Structural studies of murine I-E and human DR antigens. Mol Immunol. 1979 Jan;16(1):37–42. doi: 10.1016/0161-5890(79)90025-7. [DOI] [PubMed] [Google Scholar]
  15. Washburn L. R., Cole B. C., Ward J. R. Chronic arthritis of rabbits induced by mycoplasmas. II. Antibody response and the deposition of immune complexes. Arthritis Rheum. 1980 Jul;23(7):837–845. doi: 10.1002/art.1780230710. [DOI] [PubMed] [Google Scholar]

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