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. 1981 Feb;31(2):698–703. doi: 10.1128/iai.31.2.698-703.1981

Dengue-2 vaccine: virological, immunological, and clinical responses of six yellow fever-immune recipients.

W H Bancroft, F H Top Jr, K H Eckels, J H Anderson Jr, J M McCown, P K Russell
PMCID: PMC351366  PMID: 7216469

Abstract

Six male volunteers, previously immunized with yellow fever vaccine, were inoculated subcutaneously with a live, attenuated dengue-2 virus (PR-159/S-1) candidate vaccine. Five recipients developed viremia 8 or 9 days after vaccination, which lasted 1 to 10 days. The onset of viremia was followed by fever in three people, transient leukopenia in four, and an erythematous rash in one. One volunteer developed an oral temperature of 38.8 degrees C with headache, myalgia, fatigue, and photophobia suggestive of mild dengue fever. All five viremic volunteers developed fourfold or greater rises in serum neutralizing antibody. The sixth volunteer, who had a low titer of preexisting dengue-2 neutralizing antibody, had no viremia, no symptoms, and a modest rise in hemagglutination inhibiting antibody. Virus isolates obtained from plasma retained the small-plaque and temperature-sensitive growth characteristics of the vaccine virus in vitro. In this study, the vaccine virus genetically stable and immunogenic and seemed sufficiently attenuated for additional testing in humans.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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