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. 1981 Mar;31(3):1261–1269. doi: 10.1128/iai.31.3.1261-1269.1981

Syncytium-forming virus of common marmosets (Callithrix jacchus jacchus).

B Marczynska, C J Jones, L G Wolfe
PMCID: PMC351450  PMID: 6164648

Abstract

This communication describes the isolation and characterization of a new syncytium-forming virus of common marmosets (Callithrix jacchus jacchus). The virus, isolated from skin explants and peripheral leukocytes of healthy animals, induced syncytia and subsequent cytolysis of several human, simian, and rodent fibroblastic cultures and induced a carrier state in mixed fibroblastic-epithelial or epithelial cell lines. Cytoplasmic and nuclear viral antigen was demonstrated in infected cells by indirect immunofluorescence tests using serum obtained from persistently infected common marmosets. Abundant virus particles were detected within cisternae of endoplasmic reticulum of lytically infected cells by electron microscopy. The virus incorporated [3H]uridine, banded at a density of 1.14 to 1.16 g/cm3 in sucrose, and possessed ribonucleic acid-dependent deoxyribonucleic acid polymerase. No antigenic cross-reactivity was detected between the marmoset virus and simian foamy virus serotypes 1 to 8 in neutralization and immunofluorescence assays. A seroepidemiological survey of a marmoset colony revealed that 53.5% of common marmosets contained antibodies against the virus, whereas other species of marmosets maintained in the same colony remained free of antibodies.

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Selected References

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  1. Altaner C., Temin H. M. Carcinogenesis by RNA sarcoma viruses. XII. A quantitative study of infection of rat cells in vitro by avian sarcoma viruses. Virology. 1970 Jan;40(1):118–134. doi: 10.1016/0042-6822(70)90384-3. [DOI] [PubMed] [Google Scholar]
  2. Auersperg N. Histogenetic behavior of tumors. I. Morphologic variation in vitro and in vivo of two related human carcinoma cell lines. J Natl Cancer Inst. 1969 Jul;43(1):151–173. [PubMed] [Google Scholar]
  3. Clarke J. K., Samuels J., Dermott E., Gay F. W. Carrier cultures of simian foamy virus. J Virol. 1970 May;5(5):624–631. doi: 10.1128/jvi.5.5.624-631.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Dalton A. J., Melnick J. L., Bauer H., Beaudreau G., Bentvelzen P., Bolognesi D., Gallo R., Graffi A., Haguenau F., Heston W. The case for a family of reverse transcriptase viruses: Retraviridae. Intervirology. 1974;4(4):201–206. doi: 10.1159/000149963. [DOI] [PubMed] [Google Scholar]
  5. Falk L., Deinhardt F., Nonoyama M., Wolfe L. G., Bergholz C. Properties of a baboon lymphotropic herpesvirus related to Epstein-Barr virus. Int J Cancer. 1976 Dec 15;18(6):798–807. doi: 10.1002/ijc.2910180611. [DOI] [PubMed] [Google Scholar]
  6. Falk L., Wright J., Wolfe L., Deinhardt F. Herpesvirus ateles: transformation in vitro of marmoset splenic lymphocytes. Int J Cancer. 1974 Aug 15;14(2):244–251. doi: 10.1002/ijc.2910140213. [DOI] [PubMed] [Google Scholar]
  7. Feldman M. D., Dunnick N. R., Barry D. W., Parkman P. D. Isolation of foamy virus from rhesus, African green and cynomolgus monkey Leukocytes. J Med Primatol. 1975;4(5):287–295. doi: 10.1159/000459871. [DOI] [PubMed] [Google Scholar]
  8. Geder L., Váczi L., Jeney E. Studies on restricted growth of herpesviruses in SV40-transformed cell lines. Acta Virol. 1971 Jan;15(1):35–46. [PubMed] [Google Scholar]
  9. Gould E. A., Hartley J. Comparison of the antigens produced by foamy virus in a cytolytic and a persistent infection of HEp2 cells. J Gen Virol. 1979 Jul;44(1):235–239. doi: 10.1099/0022-1317-44-1-235. [DOI] [PubMed] [Google Scholar]
  10. Hackett A. J., Pfiester A., Arnstein P. Biological properties of a syncytia-forming agent isolated from domestic cats (feline syncytia-forming virus). Proc Soc Exp Biol Med. 1970 Dec;135(3):899–904. doi: 10.3181/00379727-135-35167. [DOI] [PubMed] [Google Scholar]
  11. Hooks J. J., Gibbs C. J., Jr, Chou S., Howk R., Lewis M., Gajdusek D. C. Isolation of a new simian foamy virus from a spider monkey brain culture. Infect Immun. 1973 Nov;8(5):804–813. doi: 10.1128/iai.8.5.804-813.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Hooks J. J., Gibbs C. J., Jr The foamy viruses. Bacteriol Rev. 1975 Sep;39(3):169–185. doi: 10.1128/br.39.3.169-185.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Johnston P. B. Taxonomic features of seven serotypes of simian and ape foamy viruses. Infect Immun. 1971 Jun;3(6):793–799. doi: 10.1128/iai.3.6.793-799.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Malmquist W. A., Van der Maaten M. J., Boothe A. D. Isolation, immunodiffusion, immunofluorescence, and electron microscopy of a syncytial virus of lymphosarcomatous and apparently normal cattle. Cancer Res. 1969 Jan;29(1):188–200. [PubMed] [Google Scholar]
  15. Marczynska B., Treu-Sarnat G., Deinhardt F. Characteristics of long-term marmoset cell cultures spontaneously altered or transformed by Rous sarcoma virus. J Natl Cancer Inst. 1970 Mar;44(3):545–572. [PubMed] [Google Scholar]
  16. Nilsson K. Transformation of lymphoid cells by herpesviruses: a review with special reference to the phenotypic properties of transformed cells. IARC Sci Publ. 1978;(24 Pt 1):451–472. [PubMed] [Google Scholar]
  17. Parks W. P., Todaro G. J., Scolnick E. M., Aaronson S. A. RNA dependent DNA polymerase in primate syncytium-forming (foamy) viruses. Nature. 1971 Jan 22;229(5282):258–260. doi: 10.1038/229258a0. [DOI] [PubMed] [Google Scholar]
  18. Périès J., Todaro G. J. A haemagglutination assay for the primate syncytium-forming (foamy) viruses. J Gen Virol. 1977 Jan;34(1):195–199. doi: 10.1099/0022-1317-34-1-195. [DOI] [PubMed] [Google Scholar]
  19. Rhodes-Feuillette A., Saal F., Lasneret J., Dubouch P., Périès J. Isolation and characterization of a new simian foamy virus serotype from lymphocytes of a Papio cynocephalus baboon. J Med Primatol. 1979;8(5):308–320. doi: 10.1159/000460216. [DOI] [PubMed] [Google Scholar]
  20. Riggs J. L., Oshirls, Taylor D. O., Lennette E. H. Syncytium-forming agent isolated from domestic cats. Nature. 1969 Jun 21;222(5199):1190–1191. doi: 10.1038/2221190a0. [DOI] [PubMed] [Google Scholar]
  21. Stenberg R., Spector D., Pizer L. Modulation of herpes simplex virus replication in adenovirus transformed cells. J Gen Virol. 1979 Aug;44(2):297–309. doi: 10.1099/0022-1317-44-2-297. [DOI] [PubMed] [Google Scholar]
  22. Wolfe L. G., Deinhardt F., Ogden J. D., Adams M. R., Fisher L. E. Reproduction of wild-caught and laboratory-born marmoset species used in biomedical research (Saguinus sp, Callithrix jacchus). Lab Anim Sci. 1975 Dec;25(6):802–813. [PubMed] [Google Scholar]
  23. Yajima Y., Marczynska B., Nonoyama M. Transforming activity of Epstein-Barr virus obtained by superinfection of Raji cells. Proc Natl Acad Sci U S A. 1978 Apr;75(4):2008–2010. doi: 10.1073/pnas.75.4.2008. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. van der Noordaa J., Enders J. F., Diamandopoulos G. T. Increased resistance to herpes simplex virus of hamster and human cells transformed by SV40. Proc Soc Exp Biol Med. 1966 Jul;122(3):915–920. doi: 10.3181/00379727-122-31289. [DOI] [PubMed] [Google Scholar]

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