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Graphical representation of the energetic impact of single substitutions on binding to Cdc13-DBD. The alternative bases substituted for each of the first four bases in Tel-11 are shown color coded by base type, adenine in red, cytosine in yellow, thymine in blue, and guanine in green. Analogs of guanine are in alternate shades of green, thio-G (S) in light green and dark green for inosine (I). The analog of thymine, uracil (U), is shown in light blue.
