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. 1981 May;32(2):415–419. doi: 10.1128/iai.32.2.415-419.1981

Nonspecific immunodepression and protective immunity in mice infected with Leishmania mexicana.

H Pérez, M Pocino, I Malavé
PMCID: PMC351458  PMID: 7019070

Abstract

C57BL/6 mice infected with Leishmania mexicana showed depression of the in vitro immunoglobulin M-plaque-forming cell response to sheep erythrocytes. Immunodepression was present 3 weeks after inoculation and was maximal at 11 weeks. Thereafter, there was a gradual return to normal immunoresponsiveness correlated with the resolution of lesions. At the time of maximal immunodepression, spleen cells from infected mice diminished the plaque-forming cell response to sheep erythrocytes of normal spleen cells. On the other hand, specific responses, as exemplified by protective immunity to a challenge infection and delayed hypersensitivity responses to parasite antigens, were apparently unaffected. These responses were both present in mice bearing primary lesions and were maximal in recovered mice. The significance of these findings is discussed in relation to a current hypothesis on parasite-induced immunodepression.

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Selected References

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  1. Arredondo B., Pérez H. Alterations of the immune response associated with chronic experimental leishmaniasis. Infect Immun. 1979 Jul;25(1):16–22. doi: 10.1128/iai.25.1.16-22.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Behin R., Mauel J., Rowe D. S. Mechanisms of protective immunity in experimental cutaneous leishmaniasis of the guinea-pig. III. Inhibition of leishmanial lesion in the guinea-pig by delayed hypersensitivity reaction to unrelated antigens. Clin Exp Immunol. 1977 Aug;29(2):320–325. [PMC free article] [PubMed] [Google Scholar]
  3. Clayton C. E., Sacks D. L., Ogilvie B. M., Askonas B. A. Membrane fractions of trypanosomes mimic the immunosuppressive and mitogenic effects of living parasites on the host. Parasite Immunol. 1979 Autumn;1(3):241–249. doi: 10.1111/j.1365-3024.1979.tb00709.x. [DOI] [PubMed] [Google Scholar]
  4. Eardley D. D., Jayawardena A. N. Suppressor cells in mice infected with Trypanosoma brucei. J Immunol. 1977 Sep;119(3):1029–1033. [PubMed] [Google Scholar]
  5. El-On J., Schnur L. F., Greenblatt C. L. Leishmania donovani: physicochemical, immunological, and biological characterization of excreted factor from promastigotes. Exp Parasitol. 1979 Apr;47(2):254–269. doi: 10.1016/0014-4894(79)90078-x. [DOI] [PubMed] [Google Scholar]
  6. Gershon R. K., Kondo K. Antigenic competition between heterologous erythrocytes. I. Thymic dependency. J Immunol. 1971 Jun;106(6):1524–1531. [PubMed] [Google Scholar]
  7. Handman E., Burgess A. W. Stimulation by granulocyte-macrophage colony-stimulating factor of Leishmania tropica killing by macrophages. J Immunol. 1979 Mar;122(3):1134–1137. [PubMed] [Google Scholar]
  8. Handman E., Spira D. T. Growth of Leishmania amastigotes in macrophages from normal and immune mice. Z Parasitenkd. 1977 Aug 25;53(1):75–81. doi: 10.1007/BF00383117. [DOI] [PubMed] [Google Scholar]
  9. Hudson K. M., Terry R. J. Immunodepression and the course of infection of a chronic Trypanosoma brucei infection in mice. Parasite Immunol. 1979 Winter;1(4):317–326. doi: 10.1111/j.1365-3024.1979.tb00717.x. [DOI] [PubMed] [Google Scholar]
  10. Jayawardena A. N., Waksman B. H. Suppressor cells in experimentally trypanosomiasis. Nature. 1977 Feb 10;265(5594):539–541. doi: 10.1038/265539a0. [DOI] [PubMed] [Google Scholar]
  11. Jerne N. K., Henry C., Nordin A. A., Fuji H., Koros A. M., Lefkovits I. Plaque forming cells: methodology and theory. Transplant Rev. 1974;18:130–191. doi: 10.1111/j.1600-065x.1974.tb01588.x. [DOI] [PubMed] [Google Scholar]
  12. Mauel J., Buchmüller Y., Behin R. Studies on the mechanisms of macrophage activation. I. Destruction of intracellular Leishmania enriettii in macrophages activated by cocultivation with stimulated lymphocytes. J Exp Med. 1978 Aug 1;148(2):393–407. doi: 10.1084/jem.148.2.393. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Mishell R. I., Dutton R. W. Immunization of dissociated spleen cell cultures from normal mice. J Exp Med. 1967 Sep 1;126(3):423–442. doi: 10.1084/jem.126.3.423. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Poulter L. W. Changes in macrophage status in vivo during infection with and immunity to Leismania enrietti. Cell Immunol. 1976 Nov;27(1):17–25. doi: 10.1016/0008-8749(76)90149-0. [DOI] [PubMed] [Google Scholar]
  15. Poulter L. W. The kinetics and quality of acquired resistance in self-healing and metastatic leishmaniasis. Clin Exp Immunol. 1979 Apr;36(1):30–37. [PMC free article] [PubMed] [Google Scholar]
  16. Preston P. M., Dumonde D. C. Experimental cutaneous leishmaniasis. V. Protective immunity in subclinical and self-healing infection in the mouse. Clin Exp Immunol. 1976 Jan;23(1):126–138. [PMC free article] [PubMed] [Google Scholar]
  17. Pross H. F., Eidinger D. Antigenic competition: a review of nonspecific antigen-induced suppression. Adv Immunol. 1974;18:133–168. doi: 10.1016/s0065-2776(08)60309-0. [DOI] [PubMed] [Google Scholar]
  18. Pérez H., Arredondo B., González M. Comparative study of American cutaneous leishmaniasis and diffuse cutaneous leishmaniasis in two strains of inbred mice. Infect Immun. 1978 Nov;22(2):301–307. doi: 10.1128/iai.22.2.301-307.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Pérez H., Arredondo B., Machado R. Leishmania mexicana and Leishmania tropica: cross immunity in C57BL/6 mice. Exp Parasitol. 1979 Aug;48(1):9–14. doi: 10.1016/0014-4894(79)90049-3. [DOI] [PubMed] [Google Scholar]
  20. Pérez H., Labrador F., Torrealba J. W. Variations in the response of five strains of mice to Leishmania mexicana. Int J Parasitol. 1979 Feb;9(1):27–32. doi: 10.1016/0020-7519(79)90062-6. [DOI] [PubMed] [Google Scholar]
  21. Pérez H., Malavé I., Arredondo B. The effects of protein malnutrition on the course of Leishmania mexicana infection in C57Bl/6 mice: nutrition and susceptibility to leishmaniasis. Clin Exp Immunol. 1979 Dec;38(3):453–460. [PMC free article] [PubMed] [Google Scholar]
  22. Schwab J. H. Suppression of the immune response by microorganisms. Bacteriol Rev. 1975 Jun;39(2):121–143. doi: 10.1128/br.39.2.121-143.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Slutzky G. M., Greenblatt C. L. Analysis by SDS-polyacrylamide gel electrophoresis of an immunologically active factor of Leishmania tropica from growth media, promastigotes, and infected macrophages. Biochem Med. 1979 Feb;21(1):70–77. doi: 10.1016/0006-2944(79)90057-7. [DOI] [PubMed] [Google Scholar]
  24. Wiedanz W. P., Rank R. G. Regional immunosuppression induced by Plasmodium berghei yoelii infection in mice. Infect Immun. 1975 Jan;11(1):211–212. doi: 10.1128/iai.11.1.211-212.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Wyler D. J., Oppenheim J. J., Koontz L. C. Influence of malaria infection on the elaboration of soluble mediators by adherent mononuclear cells. Infect Immun. 1979 Apr;24(1):151–159. doi: 10.1128/iai.24.1.151-159.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]

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