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Infection and Immunity logoLink to Infection and Immunity
. 1981 May;32(2):542–546. doi: 10.1128/iai.32.2.542-546.1981

Glucan-enhanced immunogenicity of killed erythrocyte stages of Plasmodium berghei.

T W Holbrook, J A Cook, B W Parker
PMCID: PMC351480  PMID: 7019074

Abstract

Intravenous injections of glucan simultaneously with Formalin-killed erythrocytic stages of Plasmodium berghei elicited a greater degree of resistance in mice against subsequent infection with viable parasites than injections of killed erythrocytic stages alone. In two experiments with P. berghei strain NK 65, 100% of mice immunized with the glucan-dead parasite preparation survived challenge, whereas only 28.6% of mice receiving dead parasites alone survived. In the third experiment, using P. berghei strain NYU-2, the same proportion of mice survived after immunization with glucan and dead parasites as with dead parasites alone (i.e., 10 of 11 in each group), but mice immunized with the glucan-dead parasite preparation experienced parasitemias of significantly less intensity and shorter duration than mice which received only dead parasites before infection. Inoculation of glucan alone or with normal erythrocytes conferred no protection against challenge.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Cohen S., Butcher G. A., Mitchell G. H. Immunization against erythrocytic forms of malaria parasites. Adv Exp Med Biol. 1977;93:89–112. doi: 10.1007/978-1-4615-8855-9_7. [DOI] [PubMed] [Google Scholar]
  2. Cook J. A., Holbrook T. W., Parker B. W. Visceral leishmaniasis in mice: protective effect of glucan. J Reticuloendothel Soc. 1980 Jun;27(6):567–573. [PubMed] [Google Scholar]
  3. Delville J., Jacques P. J. Therapeutic effect of yeast glucan in mice infected with Mycobacterium leprae [proceedings]. Arch Int Physiol Biochim. 1977 Dec;85(5):965–966. doi: 10.3109/13813457709053306. [DOI] [PubMed] [Google Scholar]
  4. Desowitz R. S. Plasmodium berghei: immunologic enhancement of antigen by adjuvant addition. Exp Parasitol. 1975 Aug;38(1):6–13. doi: 10.1016/0014-4894(75)90032-6. [DOI] [PubMed] [Google Scholar]
  5. Di Luzio N. R., Morrow H. S., 3rd Comparative behavior of soluble and particulate antigens and inert colloids in reticuloendothelial-stimulated or depressed mice. J Reticuloendothel Soc. 1971 Mar;9(3):273–287. [PubMed] [Google Scholar]
  6. Kokoshis P. L., Williams D. L., Cook J. A., Di Luzio N. R. Increased resistance to Staphylococcus aureus infection and enhancement in serum lysozyme activity by glucan. Science. 1978 Mar 24;199(4335):1340–1342. doi: 10.1126/science.628841. [DOI] [PubMed] [Google Scholar]
  7. MORROW S. H., DILUZIO N. R. THE FATE OF FOREIGN RED CELLS IN MICE WITH ALTERED RETICULOENDOTHELIAL FUNCTION. Proc Soc Exp Biol Med. 1965 Jul;119:647–652. doi: 10.3181/00379727-119-30261. [DOI] [PubMed] [Google Scholar]
  8. Murphy J. R., Lefford M. J. Host defenses in murine malaria: induction of a protracted state of immunity with a formalin-killed Plasmodium berghei blood parasite vaccine. Infect Immun. 1978 Dec;22(3):798–803. doi: 10.1128/iai.22.3.798-803.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Murphy J. R., Lefford M. J. Host defenses in murine malaria: successful vaccination of mice against Plasmodium berghei by using formolized blood parasites. Am J Trop Med Hyg. 1979 Jan;28(1):4–11. doi: 10.4269/ajtmh.1979.28.4. [DOI] [PubMed] [Google Scholar]
  10. Playfair J. H., De Souza J. B., Cottrell B. J. Protection of mice against malaria by a killed vaccine: differences in effectiveness against P. yoelii and P. berghei. Immunology. 1977 Oct;33(4):507–515. [PMC free article] [PubMed] [Google Scholar]
  11. Reisen W. K., Hillis T. C. Failure to protect Mus musculus against Plasmodium berghei with footpad injections of killed parasites incorporated in complete Freund's adjuvant. J Parasitol. 1975 Oct;61(5):937–940. [PubMed] [Google Scholar]
  12. Reynolds J. A., Kastello M. D., Harrington D. G., Crabbs C. L., Peters C. J., Jemski J. V., Scott G. H., Di Luzio N. R. Glucan-induced enhancement of host resistance to selected infectious diseases. Infect Immun. 1980 Oct;30(1):51–57. doi: 10.1128/iai.30.1.51-57.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. WOOLES W. R., DILUZIO N. R. RETICULOENDOTHELIAL FUNCTION AND THE IMMUNE RESPONSE. Science. 1963 Nov 22;142(3595):1078–1080. doi: 10.1126/science.142.3595.1078. [DOI] [PubMed] [Google Scholar]
  14. Williams D. L., Cook J. A., Hoffmann E. O., Di Luzio N. R. Protective effect of glucan in experimentally induced candidiasis. J Reticuloendothel Soc. 1978 Jun;23(6):479–490. [PubMed] [Google Scholar]
  15. Williams D. L., Di Luzio N. R. Glucan-induced modification of murine viral hepatitis. Science. 1980 Apr 4;208(4439):67–69. doi: 10.1126/science.7361108. [DOI] [PubMed] [Google Scholar]

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