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. Author manuscript; available in PMC: 2013 Sep 1.
Published in final edited form as: Hypertension. 2012 Jul 16;60(3):691–696. doi: 10.1161/HYPERTENSIONAHA.112.193045

Figure 5.

Figure 5

Central infusion of the ENaC blocker, benzamil largely prevents the salt-induced hypertension in Nedd 4-2 −/− mice. Panels show the day (7 am - 6 pm) and night (7 pm - 6 am) BP responses to high salt diet in −/− mice receiving either vehicle (n=4) or benzamil icv (n=5) or sc (n=5). Infusions of vehicle or benzamil (2.64 μg/day) started on day -2 and continued until the end of the study on day 10. High salt diet (8% NaCl) was given on days 0-10. Values represent the means ± SEM of the changes from baseline (average from day -1). The daytime baseline mean MAP and HR (average of day -1, in mm Hg and b/min) were: 115 ± 3 and 544 ± 28, for the icv vehicle group; 115 ± 7 and 509 ± 25, for the icv benzamil group and 108 ± 3 and 509 ± 36 for the sc benzamil group. The nighttime baseline mean MAP and HR (night -1 values, in mm Hg and b/min) were: 115 ± 2 and 543 ± 26, for the icv vehicle group; 125 ± 5 and 515 ± 30, for the icv benzamil group and 114 ± 2 and 534 ± 36 for the sc benzamil group.

* p < 0.001 vs icv benzamil group; a p < 0.05 vs sc benzamil group