Skip to main content
NCBI home page
Infection and Immunity logoLink to Infection and Immunity
. 1981 Jun;32(3):975–978. doi: 10.1128/iai.32.3.975-978.1981

Role of macrophages in resistance of mice to experimental cryptococcosis.

D P Monga
PMCID: PMC351546  PMID: 6265377

Abstract

Mice with either a stimulated or depressed reticuloendothelial system were used to study the role of macrophages in resistance to experimental Cryptococcus neoformans infection. Silica, administered intravenously to destroy macrophages, considerably decreased the phagocytic index of the reticuloendothelial system as determined by a carbon clearance test. Silica given 1 day before intravenous challenge with 5 X 10(3) (1 50% lethal dose) of C. neoformans markedly decreased the resistance of mice to cryptococcal infection. Mice given repeated doses of BCG to nonspecifically activate their macrophages could withstand a challenge of 100 50% lethal doses of C. neoformans. These results provide evidence that macrophages play an essential role in natural or nonspecific cell-mediated immunity to murine cryptococcosis.

Full text

PDF
975

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abrahams I. Further studies on acquired resistance to murine cryptococcosis: enhancing effect of Bordetella pertussis. J Immunol. 1966 Mar;96(3):525–529. [PubMed] [Google Scholar]
  2. Allison A. C., Hart P. D. Potentiation by silica of the growth of Mycobacterium tuberculosis in macrophage cultures. Br J Exp Pathol. 1968 Oct;49(5):465–476. [PMC free article] [PubMed] [Google Scholar]
  3. Bulmer G. S., Tacker J. R. Phagocytosis of Cryptococcus neoformans by alveolar macrophages. Infect Immun. 1975 Jan;11(1):73–79. doi: 10.1128/iai.11.1.73-79.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Cline M. J., Lehrer R. I. Phagocytosis by human monocytes. Blood. 1968 Sep;32(3):423–435. [PubMed] [Google Scholar]
  5. Diamond R. D. Antibody-dependent killing of Cryptococcus neopormans by human peripheral blood mononuclear cells. Nature. 1974 Jan 18;247(5437):148–150. doi: 10.1038/247148a0. [DOI] [PubMed] [Google Scholar]
  6. Diamond R. D., Bennett J. E. Disseminated cryptococcosis in man: decreased lymphocyte transformation in response to Cryptococcus neoformans. J Infect Dis. 1973 Jun;127(6):694–697. doi: 10.1093/infdis/127.6.694. [DOI] [PubMed] [Google Scholar]
  7. Diamond R. D., Bennett J. E. Growth of Cryptococcus neoformans within human macrophages in vitro. Infect Immun. 1973 Feb;7(2):231–236. doi: 10.1128/iai.7.2.231-236.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Diamond R. D., Root R. K., Bennett J. E. Factors influencing killing of Cryptococcus neoformans by human leukocytes in vitro. J Infect Dis. 1972 Apr;125(4):367–376. doi: 10.1093/infdis/125.4.367. [DOI] [PubMed] [Google Scholar]
  9. Gentry L. O., Remington J. S. Resistance against Cryptococcus conferred by intracellular bacteria and protozoa. J Infect Dis. 1971 Jan;123(1):22–31. doi: 10.1093/infdis/123.1.22. [DOI] [PubMed] [Google Scholar]
  10. Graybill J. R., Drutz D. J. Host defense in cryptococcosis. II. Cryptococcosis in the nude mouse. Cell Immunol. 1978 Oct;40(2):263–274. doi: 10.1016/0008-8749(78)90334-9. [DOI] [PubMed] [Google Scholar]
  11. Graybill J. R., Mitchell L., Drutz D. J. Host defense in cryptococcosis. III. Protection of nude mice by thymus transplantation. J Infect Dis. 1979 Oct;140(4):546–552. doi: 10.1093/infdis/140.4.546. [DOI] [PubMed] [Google Scholar]
  12. Karaoui R. M., Hall N. K., Larsh H. W. Role of macrophages in immunity and pathogenesis of experimental cryptococcosis induced by the airborne route--Part II: Phagocytosis and intracellular fate of Cryptococcus neoformans. Mykosen. 1977 Nov;20(11):409–412. [PubMed] [Google Scholar]
  13. Levy M. H., Wheelock E. F. Effects of intravenous silica on immune and non-immune functions of the murine host. J Immunol. 1975 Jul;115(1):41–48. [PubMed] [Google Scholar]
  14. MACKANESS G. B. Cellular resistance to infection. J Exp Med. 1962 Sep 1;116:381–406. doi: 10.1084/jem.116.3.381. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Mackaness G. B. The immunology of antituberculous immunity. Am Rev Respir Dis. 1968 Mar;97(3):337–344. doi: 10.1164/arrd.1968.97.3.337. [DOI] [PubMed] [Google Scholar]
  16. Mitchell T. G., Friedman L. In vitro phagocytosis and intracellular fate of variously encapsulated strains of Cryptococcus neoformans. Infect Immun. 1972 Apr;5(4):491–498. doi: 10.1128/iai.5.4.491-498.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Mokyr M. B., Mitchell M. S. Activation of lymphoid cells by BCG in vitro. Cell Immunol. 1975 Feb;15(2):264–273. doi: 10.1016/0008-8749(75)90005-2. [DOI] [PubMed] [Google Scholar]
  18. Monga D. P., Kumar R., Mohapatra L. N., Malaviya A. N. Experimental cryptococcosis in normal and B-cell-deficient mice. Infect Immun. 1979 Oct;26(1):1–3. doi: 10.1128/iai.26.1.1-3.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Monga D. P., Kumar R., Mohapatra L. N., Malaviya A. N. Experimental cryptococcosis in normal and T cell deficient mice. Indian J Med Res. 1980 Nov;72:641–649. [PubMed] [Google Scholar]
  20. O'Brien A. D., Scher I., Formal S. B. Effect of silica on the innate resistance of inbred mice to Salmonella typhimurium infection. Infect Immun. 1979 Aug;25(2):513–520. doi: 10.1128/iai.25.2.513-520.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES