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. 1981 Jun;32(3):1093–1099. doi: 10.1128/iai.32.3.1093-1099.1981

Immunization against bacteria- and endotoxin-induced hypotension.

A M Abdelnoor, A G Johnson, A Anderson-Imbert, A Nowotny
PMCID: PMC351563  PMID: 7251158

Abstract

The characteristics of hypotension induced in rabbits by intravenous injection of viable Salmonella typhosa 0901 organisms were studied and found to be a function of the number and age of the bacterial cells. Effective neutralization of the blood pressure lowering was achieved by immunization with homologous organisms as well as heterologous endotoxins and a detoxified derivative. In addition, native endotoxins derived from a number of different genera of gram-negative bacilli, as well as lipopolysaccharides deficient in either the polysaccharide or lipid components, were tested for their ability to induce hypotension in rabbits and tolerance to the lowering of blood pressure. Hypotension was elicited by intravenous injection of all native endotoxins as well as polysaccharide-deficient endotoxins, but was absent in preparations from which the lipid was removed. On the other hand, protection against the hypotension effect could be induced after injection of either the lipid- or polysaccharide-deficient derivatives.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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