Abstract
Blood compatibility is a major objective in the development of long-term, implantable circulatory assist (left ventricular assist devices) and replacement (total artificial heart) devices. An important problem in experimental studies in animals has been the propensity for calcification to occur at the blood/material interface. Presented is a summary of our experience (27 studies) with blood pump calcification and a review of the current literature regarding this complication.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Harasaki H., Gerrity R., Kiraly R., Jacobs G., Nosé Y. Calcification in blood pumps. Trans Am Soc Artif Intern Organs. 1979;25:305–310. doi: 10.1097/00002480-197902500-00055. [DOI] [PubMed] [Google Scholar]
- Harasaki H., Kambic H., Whalen R., Murray J., Snow J., Murabayashi S., Hillegass D., Ozawa K., Kiraly R., Nosé Y. Comparative study of flocked vs biolized surface for long-term assist pumps. Trans Am Soc Artif Intern Organs. 1980;26:470–474. [PubMed] [Google Scholar]
- Oyer P. E., Stinson E. B., Portner P. M., Ream A. K., Shumway N. E. Development of a totally implantable, electrically actuated left ventricular assist system. Am J Surg. 1980 Jul;140(1):17–25. doi: 10.1016/0002-9610(80)90412-2. [DOI] [PubMed] [Google Scholar]
- Pierce W. S., Donachy J. H., Rosenberg G., Baier R. E. Calcification inside artificial hearts: inhibition by warfarin-sodium. Science. 1980 May 9;208(4444):601–603. doi: 10.1126/science.7367883. [DOI] [PubMed] [Google Scholar]
- Pierce W. S., Myers J. L., Donachy J. H., Rosenberg G., Landis D. L., Prophet G. A., Snyder A. J. Approaches to the artificial heart. Invited speaker. Surgery. 1981 Aug;90(2):137–148. [PubMed] [Google Scholar]
- Szycher M., Poirier V., Bernhard W. F., Franzblau C., Haudenschild C. C., Toselli P. Integrally textured polymeric surfaces for permanently implantable cardiac assist devices. Trans Am Soc Artif Intern Organs. 1980;26:493–497. [PubMed] [Google Scholar]
- Turner S. A., Milton L. T., Poirier V. L., Norman J. C. Sequential studies of pseudoneointimae within long-term THI E-type ALVAD's thickness, calcification and compositional analyses. Artif Organs. 1981 Feb;5(1):18–25. [PubMed] [Google Scholar]
- Whalen R. L., Snow J. L., Harasaki H., Nosé Y. Mechanical strain and calcification in blood pumps. Trans Am Soc Artif Intern Organs. 1980;26:487–492. [PubMed] [Google Scholar]