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. Author manuscript; available in PMC: 2013 Mar 5.
Published in final edited form as: Chemistry. 2012 Feb 3;18(10):2948–2960. doi: 10.1002/chem.201102898

Scheme 16.

Scheme 16

Optimization of the Key Rh-Catalyzed Cycloisomerization

Entry Phosphine (equiv) Time (h) Yield (%)[a]
1 76 (1.1) 2 40
2 77 (1.1) 2 50
3 77 (1.1) 18 Decomposed
4 78 (1.1) 2 48
5 79 (1.1) 18 NR
6 79 (0.2) 5 60
7 79 (0.1) 5 55
8 79 (0.1) 5 15[b]
[a]
Isolated yield;
[b]
CSA, 1 equiv was used