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. 1984 Dec;11(4):344–347.

Coronary Thrombolysis with Tissue-Type Plasminogen Activator: Prospective Review

Désiré Collen 1
PMCID: PMC351707  PMID: 15226873

Abstract

Coronary thrombolysis is not a goal in itself, but is employed to prevent necrotic dysfunction of jeopardized myocardial cells. It is being increasingly investigated as a treatment for acute myocardial infarction, which is often associated with thrombotic occlusion of an atherosclerotic coronary artery. The administration of thrombolytic agents has been shown to reopen an occluded coronary artery in the majority of such cases. Briefly summarized are studies performed to date in animal models and in patients with acute myocardial infarction.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Anderson J. L., Marshall H. W., Bray B. E., Lutz J. R., Frederick P. R., Yanowitz F. G., Datz F. L., Klausner S. C., Hagan A. D. A randomized trial of intracoronary streptokinase in the treatment of acute myocardial infarction. N Engl J Med. 1983 Jun 2;308(22):1312–1318. doi: 10.1056/NEJM198306023082202. [DOI] [PubMed] [Google Scholar]
  2. Bergmann S. R., Fox K. A., Ter-Pogossian M. M., Sobel B. E., Collen D. Clot-selective coronary thrombolysis with tissue-type plasminogen activator. Science. 1983 Jun 10;220(4602):1181–1183. doi: 10.1126/science.6602378. [DOI] [PubMed] [Google Scholar]
  3. Bergmann S. R., Lerch R. A., Fox K. A., Ludbrook P. A., Welch M. J., Ter-Pogossian M. M., Sobel B. E. Temporal dependence of beneficial effects of coronary thrombolysis characterized by positron tomography. Am J Med. 1982 Oct;73(4):573–581. doi: 10.1016/0002-9343(82)90338-2. [DOI] [PubMed] [Google Scholar]
  4. Collen D., Rijken D. C., Van Damme J., Billiau A. Purification of human tissue-type plasminogen activator in centigram quantities from human melanoma cell culture fluid and its conditioning for use in vivo. Thromb Haemost. 1982 Dec 27;48(3):294–296. [PubMed] [Google Scholar]
  5. Collen D., Stassen J. M., Verstraete M. Thrombolysis with human extrinsic (tissue-type) plasminogen activator in rabbits with experimental jugular vein thrombosis. Effect of molecular form and dose of activator, age of the thrombus, and route of administration. J Clin Invest. 1983 Feb;71(2):368–376. doi: 10.1172/JCI110778. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. DeWood M. A., Spores J., Notske R., Mouser L. T., Burroughs R., Golden M. S., Lang H. T. Prevalence of total coronary occlusion during the early hours of transmural myocardial infarction. N Engl J Med. 1980 Oct 16;303(16):897–902. doi: 10.1056/NEJM198010163031601. [DOI] [PubMed] [Google Scholar]
  7. Gold H. K., Fallon J. T., Yasuda T., Leinbach R. C., Khaw B. A., Newell J. B., Guerrero J. L., Vislosky F. M., Hoyng C. F., Grossbard E. Coronary thrombolysis with recombinant human tissue-type plasminogen activator. Circulation. 1984 Oct;70(4):700–707. doi: 10.1161/01.cir.70.4.700. [DOI] [PubMed] [Google Scholar]
  8. Kennedy J. W., Ritchie J. L., Davis K. B., Fritz J. K. Western Washington randomized trial of intracoronary streptokinase in acute myocardial infarction. N Engl J Med. 1983 Dec 15;309(24):1477–1482. doi: 10.1056/NEJM198312153092402. [DOI] [PubMed] [Google Scholar]
  9. Khaja F., Walton J. A., Jr, Brymer J. F., Lo E., Osterberger L., O'Neill W. W., Colfer H. T., Weiss R., Lee T., Kurian T. Intracoronary fibrinolytic therapy in acute myocardial infarction. Report of a prospective randomized trial. N Engl J Med. 1983 Jun 2;308(22):1305–1311. doi: 10.1056/NEJM198306023082201. [DOI] [PubMed] [Google Scholar]
  10. Korninger C., Matsuo O., Suy R., Stassen J. M., Collen D. Thrombolysis with human extrinsic (tissue-type) plasminogen activator in dogs with femoral vein thrombosis. J Clin Invest. 1982 Mar;69(3):573–580. doi: 10.1172/JCI110483. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Matsuo O., Rijken D. C., Collen D. Thrombolysis by human tissue plasminogen activator and urokinase in rabbits with experimental pulmonary embolus. Nature. 1981 Jun 18;291(5816):590–591. doi: 10.1038/291590a0. [DOI] [PubMed] [Google Scholar]
  12. Pennica D., Holmes W. E., Kohr W. J., Harkins R. N., Vehar G. A., Ward C. A., Bennett W. F., Yelverton E., Seeburg P. H., Heyneker H. L. Cloning and expression of human tissue-type plasminogen activator cDNA in E. coli. Nature. 1983 Jan 20;301(5897):214–221. doi: 10.1038/301214a0. [DOI] [PubMed] [Google Scholar]
  13. Rentrop P., Blanke H., Karsch K. R., Kaiser H., Köstering H., Leitz K. Selective intracoronary thrombolysis in acute myocardial infarction and unstable angina pectoris. Circulation. 1981 Feb;63(2):307–317. doi: 10.1161/01.cir.63.2.307. [DOI] [PubMed] [Google Scholar]
  14. Schröder R., Biamino G., von Leitner E. R., Linderer T., Brüggemann T., Heitz J., Vöhringer H. F., Wegscheider K. Intravenous short-term infusion of streptokinase in acute myocardial infarction. Circulation. 1983 Mar;67(3):536–548. doi: 10.1161/01.cir.67.3.536. [DOI] [PubMed] [Google Scholar]
  15. Sobel B. E., Geltman E. M., Tiefenbrunn A. J., Jaffe A. S., Spadaro J. J., Jr, Ter-Pogossian M. M., Collen D., Ludbrook P. A. Improvement of regional myocardial metabolism after coronary thrombolysis induced with tissue-type plasminogen activator or streptokinase. Circulation. 1984 May;69(5):983–990. doi: 10.1161/01.cir.69.5.983. [DOI] [PubMed] [Google Scholar]
  16. Van de Werf F., Bergmann S. R., Fox K. A., de Geest H., Hoyng C. F., Sobel B. E., Collen D. Coronary thrombolysis with intravenously administered human tissue-type plasminogen activator produced by recombinant DNA technology. Circulation. 1984 Mar;69(3):605–610. doi: 10.1161/01.cir.69.3.605. [DOI] [PubMed] [Google Scholar]
  17. Van de Werf F., Ludbrook P. A., Bergmann S. R., Tiefenbrunn A. J., Fox K. A., de Geest H., Verstraete M., Collen D., Sobel B. E. Coronary thrombolysis with tissue-type plasminogen activator in patients with evolving myocardial infarction. N Engl J Med. 1984 Mar 8;310(10):609–613. doi: 10.1056/NEJM198403083101001. [DOI] [PubMed] [Google Scholar]
  18. Walker I. D., Davidson J. F., Rae A. P., Hutton I., Lawrie T. D. Acylated streptokinase--plasminogen complex in patients with acute myocardial infarction. Thromb Haemost. 1984 Apr 30;51(2):204–206. [PubMed] [Google Scholar]
  19. Weimar W., Stibbe J., van Seyen A. J., Billiau A., De Somer P., Collen D. Specific lysis of an iliofemoral thrombus by administration of extrinsic (tissue-type) plasminogen activator. Lancet. 1981 Nov 7;2(8254):1018–1020. doi: 10.1016/s0140-6736(81)91217-4. [DOI] [PubMed] [Google Scholar]

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