Table 4.
Task | ROI | Variant | Gene | Direction of Effecta | p-value | q-valued |
---|---|---|---|---|---|---|
AC | RLOTG | rsSTR (allele 8) | DCDC2 | -0.319 | 0.0001 | 0.0490 |
AC | LMOTG | rs1087266 | DCDC2 | 0.033 | 0.0080 | 0.8337 |
PC | LPC | rsSTR (allele 1) | DCDC2 | -0.026 | 0.0032 | 0.7824 |
PC | LAIPL | rs793862 | DCDC2 | 0.027 | 0.0065 | 0.9509 |
PC | LAIPL | rsSTR (allele 4) | DCDC2 | 0.08 | 0.00003 | 0.0442 |
PC | RLOTG | rsSTR (allele 8) | DCDC2 | -0.263 | 0.00008 | 0.0588 |
PC | LMOTG | rs793862 | DCDC2 | 0.023 | 0.0074 | 0.9835 |
PC | LMOTG | rsSTR (allele 4) | DCDC2 | 0.046 | 0.0076 | 0.9253 |
WR | SAC | rsSTR (allele 5) | DCDC2 | 0.096 | 0.0083 | 0.8068 |
WR | RAIPL | rs2143340 | TTRAP | -0.029 | 0.0038 | 0.7425 |
WR | LAIPL | rs2143340 | TTRAP | -0.024 | 0.0029 | 0.8514 |
NWR | LIFGI | rs1087266 | DCDC2 | 0.02 | 0.0038 | 0.7425 |
NWR | LPC | rsSTR (deletion)b | DCDC2 | 0.042 | 0.0050 | 0.8133 |
NWR | LPC | rsdelc | DCDC2 | 0.039 | 0.0079 | 0.8872 |
NWR | PC | rsSTR (allele 8) | DCDC2 | -0.02 | 0.0016 | 0.5876 |
For SNPs, the direction of effect refers to allele 1 (see Supplementary Table S3), allele 2 has the opposite effect.
multiallelic association (all STR alleles)
biallelic association (presence/absence of the BV677278 deletion)
q-values were calculated by the Benjamini and Hochberg method of False Discovery Rate (FDR) correction for multiple testing with 1472 hypotheses of imaging-genetic associations performed. Those in bold reached or trended toward statistical significance after FDR correction for multiple testing.