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. 1977 Jan;11(1):167–170. doi: 10.1128/aac.11.1.167

Nalidixic Acid-Induced Protein Alterations in Escherichia coli

Lee Chao 1
PMCID: PMC351937  PMID: 319748

Abstract

The effect of nalidixic acid on pulse-labeled protein patterns was analyzed by sodium dodecyl sulfate-polyacrylamide slab gel electrophoresis. The drug was found to alter protein patterns in a drug-sensitive strain but not in the isogenic drug-resistant strain of Escherichia coli. The drug-induced alteration of protein patterns was demonstrated by the appearance of some and the disappearance of other pulse-labeled peptides elicited by the drug.

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Selected References

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