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. 1977 Feb;11(2):229–233. doi: 10.1128/aac.11.2.229

Effects of Purines and Pyrimidines on the Fungistatic Activity of 5-Fluorocytosine in Aspergillus Species

Gerald E Wagner 1, Smith Shadomy 1
PMCID: PMC351958  PMID: 848925

Abstract

The ability of some exogenously supplied purines, pyrimidines, and their nucleosides to antagonize the in vitro fungistatic activity of 5-fluorocytosine (5-FC) in Aspergillus species was examined. All compounds tested except thymidine were capable of altering the minimal inhibitory concentration of 5-FC for seven strains of aspergilli tested. In most instances, there was a reciprocal correlation between the ability of a compound to antagonize the fungistatic activity of 5-FC and the quantity of 5-FC taken up by cells in the presence of the compound over a 72-h period.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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