Abstract
The effect of amphotericin B on CO2 production was studied using a Bactec 225. A radiometric procedure for yeast susceptibility testing that requires 3 h of incubation was developed. A total of 48 yeast isolates was tested in this system and the results were correlated to tube dilution studies. The drug concentration causing at least a 44% decrease in CO2 production correlated to the tube dilution minimal inhibitory concentration in 85% of isolates tested and was within one tube dilution of the minimal inhibitory concentration in over 95% of yeasts tested.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Benitez P., Medoff G., Kobayashi G. S. Rapid radiometric method of testing susceptibility of mycobacteria and slow-growing fungi to antimicrobial agents. Antimicrob Agents Chemother. 1974 Jul;6(1):29–33. doi: 10.1128/aac.6.1.29. [DOI] [PMC free article] [PubMed] [Google Scholar]
- DeBlanc H. J., Jr, Charache P., Wagner H. N., Jr Automatic radiometric measurement of antibiotic effect on bacterial growth. Antimicrob Agents Chemother. 1972 Nov;2(5):360–366. doi: 10.1128/aac.2.5.360. [DOI] [PMC free article] [PubMed] [Google Scholar]
- DeLand F. H. Metabolic inhibition as an index of bacterial susceptibility to drugs. Antimicrob Agents Chemother. 1972 Nov;2(5):405–412. doi: 10.1128/aac.2.5.405. [DOI] [PMC free article] [PubMed] [Google Scholar]