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Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1977 Mar;11(3):388–391. doi: 10.1128/aac.11.3.388

Changing Patterns of Plasmid-Mediated Drug Resistance During Tetracycline Therapy

J K Møller *, A Leth Bak 1, A Stenderup 1, H Zachariae 1, H Afzelius 1
PMCID: PMC351994  PMID: 140624

Abstract

The patterns of drug resistance and the frequency of conjugative R plasmids in intestinal Escherichia coli from 88 patients treated for a skin disease (acne vulgaris) with low oral doses of tetracycline are reported. The proportion of patients with resistant bacteria was progressively greater in patients who received tetracycline for 1 week, 4 weeks, or longer (from 50 to 88%). No multiply drug-resistant bacteria were detected before treatment or after 1 week of treatment. After more than 4 weeks of treatment, multiply drug-resistant E. coli were isolated from about 50% of the patients. The origin and selection of R plasmid-determined multiple drug resistance are discussed.

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Selected References

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