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. 1977 Mar;11(3):402–406. doi: 10.1128/aac.11.3.402

Antibacterial Activity of Netilmicin, a New Aminoglycoside Antibiotic, Compared with That of Gentamicin

Ian Phillips 1, Anne Smith 1, Kevin Shannon 1
PMCID: PMC351997  PMID: 301004

Abstract

The antibacterial activity of netilmicin (Sch 20569), a new semisynthetic aminoglycoside, was compared with that of gentamicin against a variety of gram-negative bacteria, staphylococci, and streptococci. Both antibiotics had similar activity against most organisms, but netilmicin had appreciably greater activity against gram-negative organisms that were resistant to gentamicin because these species synthesized aminoglycoside 3-N-acetyltransferase I or aminoglycoside 2″-O-nucleotidyltransferase. Netilmicin was also more active than gentamicin against gentamicin-resistant strains of Staphylococcus aureus that produced two enzymes–aminoglycoside-2″-O-phosphotransferase and aminoglycoside-6′-N-acetyltransferase.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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