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. 1977 Mar;11(3):491–499. doi: 10.1128/aac.11.3.491

Inhibition of Initiation, Elongation, and Termination of Eukaryotic Protein Synthesis by Trichothecene Fungal Toxins

Eric Cundliffe 1,1, Julian E Davies 1
PMCID: PMC352012  PMID: 856003

Abstract

The 12,13-epoxytrichothecenes, specific inhibitors of protein synthesis in eukaryotes, can be subdivided further in terms of their mode of action. In addition to the I-type (initiation inhibitors) and E-types (elongation inhibitors), we found that some E-types apparently exhibit inhibition of chain termination at low concentrations. The nature of substituents on C4 may determine the type of inhibitory activity observed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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