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. 1977 May;11(5):791–796. doi: 10.1128/aac.11.5.791

In Vitro Activity of Netilmicin Compared with Gentamicin, Tobramycin, Amikacin, and Kanamycin

Theodore C Eickhoff 1, Josephine M Ehret 1
PMCID: PMC352076  PMID: 879733

Abstract

The in vitro activity of netilmicin was compared with that of gentamicin, tobramycin, amikacin, and kanamycin against 636 strains of bacteria recently isolated from clinical sources. Gentamicin was the most active antibiotic, but netilmicin and tobramycin closely paralleled it. Netilmicin was generally four-to eightfold less active than gentamicin against Serratia and group A streptococci, and was twofold less active against Pseudomonas aeruginosa. When effects of inoculum size and concentration of divalent cations in the media were evaluated, netilmicin was shown to be similar to gentamicin in vitro. Minimum inhibitory concentrations for P. aeruginosa were increased as much as 18-fold when the Mg2+ and Ca2+ concentrations were increased to physiological levels in Mueller-Hinton broth.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BULGER R. J., SIDELL S., KIRBY W. M. LABORATORY AND CLINICAL STUDIES OF GENTAMICIN, A NEW BROAD-SPECTRUM ANTIBIOTIC. Ann Intern Med. 1963 Nov;59:593–604. doi: 10.7326/0003-4819-59-5-593. [DOI] [PubMed] [Google Scholar]
  2. Bauer A. W., Kirby W. M., Sherris J. C., Turck M. Antibiotic susceptibility testing by a standardized single disk method. Am J Clin Pathol. 1966 Apr;45(4):493–496. [PubMed] [Google Scholar]
  3. Chang J. C., Reyes B. Agranulocytosis associated with gentamicin. JAMA. 1975 Jun 16;232(11):1154–1155. [PubMed] [Google Scholar]
  4. Davis S. D., Iannetta A. Relative antagonism in vitro of calcium in serum to the bactericidal activities of gentamicin and tobramycin on Pseudomonas aeruginosa. Chemotherapy. 1973 Oct;19(4):243–253. doi: 10.1159/000221461. [DOI] [PubMed] [Google Scholar]
  5. Eickhoff T. C. New antibacterial treatment of nosocomial infections. Bull N Y Acad Med. 1975 Oct;51(9):1056–1064. [PMC free article] [PubMed] [Google Scholar]
  6. Falco F. G., Smith H. M., Arcieri G. M. Nephrotoxicity of aminoglycosides and gentamicin. J Infect Dis. 1969 Apr-May;119(4):406–409. doi: 10.1093/infdis/119.4-5.406. [DOI] [PubMed] [Google Scholar]
  7. Finland M. Changing ecology of bacterial infections as related to antibacterial therapy. J Infect Dis. 1970 Nov;122(5):419–431. doi: 10.1093/infdis/122.5.419. [DOI] [PubMed] [Google Scholar]
  8. Gilbert D. N., Kutscher E., Ireland P., Barnett J. A., Sanford J. P. Effect of the concentrations of magnesium and calcium on the in-vitro susceptibility of Pseudomonas aeruginosa to gentamicin. J Infect Dis. 1971 Dec;124 (Suppl):S37–S45. doi: 10.1093/infdis/124.supplement_1.s37. [DOI] [PubMed] [Google Scholar]
  9. Holtzman J. L. Letter: Gentamicin and neuromuscular blockade. Ann Intern Med. 1976 Jan;84(1):55–55. doi: 10.7326/0003-4819-84-1-55_1. [DOI] [PubMed] [Google Scholar]
  10. Houang E. T., McKay-Ferguson E. Letter: Activities of tobramycin and amikacin against gentamicin-resistant gram-negative bacilli. Lancet. 1976 Feb 21;1(7956):423–424. doi: 10.1016/s0140-6736(76)90253-1. [DOI] [PubMed] [Google Scholar]
  11. Jackson G. G., Arcieri G. Ototoxicity of gentamicin in man: a survey and controlled analysis of clinical experience in the United States. J Infect Dis. 1971 Dec;124 (Suppl):S130–S137. doi: 10.1093/infdis/124.supplement_1.s130. [DOI] [PubMed] [Google Scholar]
  12. Jackson G. G. Current therapeutics. 234. Gentamicin. Practitioner. 1967 Jun;198(188):855–866. [PubMed] [Google Scholar]
  13. KLEIN J. O., EICKHOFF T. C., FINLAND M. GENTAMICIN: ACTIVITY IN VITRO AND OBSERVATIONS IN 26 PATIENTS. Am J Med Sci. 1964 Nov;248:528–544. [PubMed] [Google Scholar]
  14. Martin C. M., Ikari N. S., Zimmerman J., Waitz J. A. A virulent nosocomial Klebsiella with a transferable R factor for gentamicin: emergence and suppression. J Infect Dis. 1971 Dec;124 (Suppl):S24–S29. doi: 10.1093/infdis/124.supplement_1.s24. [DOI] [PubMed] [Google Scholar]
  15. Meyer R. D., Lewis R. P., Halter J., White M. Gentamicin-resistant Pseudomonas aeruginosa and Serratia marcescens in a general hospital. Lancet. 1976 Mar 13;1(7959):580–583. doi: 10.1016/s0140-6736(76)90370-6. [DOI] [PubMed] [Google Scholar]
  16. Warren R. E., Roberts S. O. Letter: Gentamicin-resistant Staphylococci. Lancet. 1976 Mar 6;1(7958):543–544. doi: 10.1016/s0140-6736(76)90336-6. [DOI] [PubMed] [Google Scholar]
  17. Wilfert J. N., Burke J. P., Bloomer H. A., Smith C. B. Renal insufficiency associated with gentamicin therapy. J Infect Dis. 1971 Dec;124 (Suppl):S148–S155. doi: 10.1093/infdis/124.supplement_1.s148. [DOI] [PubMed] [Google Scholar]

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