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. 1977 May;11(5):813–816. doi: 10.1128/aac.11.5.813

Synergistic Action of Erythromycin and Cefamandole Against Bacteroides fragilis Subsp. fragilis

R S Griffith *, G L Brier 1, J D Wolny 1
PMCID: PMC352080  PMID: 879736

Abstract

Erythromycin and cefamandole have exhibited synergistic activity against eight strains of Bacteroides fragilis subsp. fragilis. In concentrations of only 0.25 to 0.5 μg of erythromycin per ml (easily obtainable with oral therapy), less than 0.4 μg (0.015 to 1.0) of cefamandole per ml inhibited the B. fragilis strains. In the presence of the erythromycin, the potency of cefamandole was increased more than 100-fold. On the basis of the mechanism of action of these two antibiotics, the synergism may be related to inhibition of beta-lactamase formation by the erythromycin, removal of the bacterial cell wall by the cefamandole permitting erythromycin penetration to the ribosomal level, and decreasing inoculum effect.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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