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. 1977 May;11(5):871–876. doi: 10.1128/aac.11.5.871

Inducible Resistance to d-Cycloserine in Bacillus subtilis 168

Virginia L Clark a,1, Frank E Young a
PMCID: PMC352089  PMID: 406831

Abstract

Resistance to d-cycloserine could be induced in Bacillus subtilis 168 by sublethal concentrations of d-cycloserine. Sensitivity to the antibiotic could be regained by growth in the absence of d-cycloserine. The bactericidal activity of d-cycloserine apparently was not altered by resistant cells, and peptidoglycan synthesis was still inhibited by d-cycloserine in resistant cells. The d-cycloserine resistance apparently resulted from a decreased uptake of the antibiotic. The decrease in d-cycloserine transport could be prevented by simultaneous treatment of the cells with rifampin and d-cycloserine. d-Cycloserine was transported by the same system as glycine in B. subtilis. d-Cycloserine was able to exchange for intracellular glycine in both sensitive and resistant cells, suggesting that d-cycloserine is not excluded from the cell in resistant cultures.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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