Abstract
In cats that had high, sustained serum concentrations of cephradine, penetration of the drug into the cerebrospinal fluid (CSF) was poor. Serum cephradine levels were, on the average, 100-fold higher than the CSF levels. On the other hand, the direct injection of cephradine into the lateral cerebral ventricles of cats yielded high CSF cephradine concentrations without evidence of central nervous system toxicity.
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Selected References
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- Bassaris H. P., Quintiliani R., Maderazo E. G., Tilton R. C., Nightingale C. H. Pharmacokinetics and penetration characteristics of cefazolin into human spinal fluid. Curr Ther Res Clin Exp. 1976 Jan;19(1):110–120. [PubMed] [Google Scholar]
- Fisher L. S., Chow A. W., Yoshikawa T. T., Guze L. B. Cephalothin and cephaloridine therapy for bacterial meningitis. Ann Intern Med. 1975 May;82(5):689–693. doi: 10.7326/0003-4819-82-5-689. [DOI] [PubMed] [Google Scholar]
- Lerner P. I. Penetration of cephalothin and lincomycin into the cerebrospinal fluid. Am J Med Sci. 1969 Feb;257(2):125–131. doi: 10.1097/00000441-196902000-00006. [DOI] [PubMed] [Google Scholar]
- Love W. C., McKenzie P., Lawson J. H., Pinkerton I. W., Jamieson W. M., Stevenson J., Roberts W., Christie A. B. Treatment of pneumococcal meningitis with cephaloridine. Postgrad Med J. 1970 Oct;(Suppl):155–159. [PubMed] [Google Scholar]
- Mangi R. J., Kundargi R. S., Quintiliani R., Andriole V. T. Development of meningitis during cephalothin therapy. Ann Intern Med. 1973 Mar;78(3):347–351. doi: 10.7326/0003-4819-78-3-347. [DOI] [PubMed] [Google Scholar]
- Vianna N. J., Kaye D. Penetration of cephalothin into the spinal fluid. Am J Med Sci. 1967 Aug;254(2):216–220. doi: 10.1097/00000441-196708000-00012. [DOI] [PubMed] [Google Scholar]