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. 1977 May;11(5):919–922. doi: 10.1128/aac.11.5.919

Phosphonoacetic Acid-Resistant Mutants of Herpes Simplex Virus: Effect of Phosphonoacetic Acid on Virus Replication and In Vitro Deoxyribonucleic Acid Synthesis in Isolated Nuclei

Yechiel Becker 1, Yael Asher 1, Yaffa Cohen 1, Eynat Weinberg-Zahlering 1, Joseph Shlomai 1
PMCID: PMC352099  PMID: 195514

Abstract

Phosphonoacetic acid (PAA) inhibits the replication of herpes simplex virus in BSC-1 cells and the in vitro synthesis of deoxyribonucleic acid (DNA) in isolated nuclei. Phosphonopropionic acid at a concentration of 100 μg/ml had no effect on herpes simplex virus replication. PAA-resistant mutants were obtained at a rate of 1 in 104 plaque-forming units after 5-bromodeoxyuridine mutagenization of the virus. These mutants replicate in BSC-1 cells in the presence of 100 μg of PAA per ml and induce a PAA-resistant DNA polymerase that synthesizes DNA in vitro in the presence of PAA.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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