Table 2.

Body weight, adiposity and serum leptin levels with short-term leptin overexpression.

	rAAV-Control	rAAV-Leptin into VTA	rAAV-Leptin into MBH
BW, g	332 ± 4a	304 ± 8c	294 ± 6b
Adiposity, g	83.6 ± 1.5a	65.0 ± 2.3b	61.6 ± 3.0b
WAT, g	6.9 ± 0.3a	3.7 ± 0.3b	3.4 ± 1.1b
Serum Leptin, ng/ml	3.3 ± 0.5a	1.4 ± 0.4b	1.3 ± 0.3c

Data represent the mean ± SE of 7-8 rats per group.

Adiposity was determined by TD-NMR prior to death at day 9.

WAT represents the sum of PWAT, RTWAT, and EWAT at death.

^aP<0.001 for difference with treatment at day 9 by one-way ANOVA.

^bP<0.01 for difference from control group by post-hoc analysis.

^cP<0.05 for difference from control group by post-hoc analysis.