Abstract
The serum pharmacokinetics of amikacin were studied in 36 infants treated for suspected bacterial infection. A prolonged serum half-life was associated with the related variables of birth at an early gestational age, low birth weight, and hypoxemia. A postnatal age effect was not apparent when hypoxemic infants were excluded.
Full text
PDF





Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bodey G. P., Valdivieso M., Feld R., Rodriguez V. Pharmacology of amikacin in humans. Antimicrob Agents Chemother. 1974 May;5(5):508–512. doi: 10.1128/aac.5.5.508. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Clarke J. T., Libke R. D., Regamey C., Kirby W. M. Comparative pharmacokinetics of amikacin and kanamycin. Clin Pharmacol Ther. 1974 Jun;15(6):610–616. doi: 10.1002/cpt1974156610. [DOI] [PubMed] [Google Scholar]
- Cox C. E. Gentamicin. Med Clin North Am. 1970 Sep;54(5):1305–1315. [PubMed] [Google Scholar]
- Dubowitz L. M., Dubowitz V., Goldberg C. Clinical assessment of gestational age in the newborn infant. J Pediatr. 1970 Jul;77(1):1–10. doi: 10.1016/s0022-3476(70)80038-5. [DOI] [PubMed] [Google Scholar]
- Dunne J. T., Milligan J. E., Thomas B. W. Control of renal circulation in the fetus. Am J Obstet Gynecol. 1972 Feb 1;112(3):323–329. doi: 10.1016/0002-9378(72)90471-1. [DOI] [PubMed] [Google Scholar]
- Echeverria P., Siber G. R., Paisley J., Smith A. L., Smith D. H., Jaffe N., Paed D. Age-dependent dose response to gentamicin. J Pediatr. 1975 Nov;87(5):805–808. doi: 10.1016/s0022-3476(75)80316-7. [DOI] [PubMed] [Google Scholar]
- Franco J. A., Eitzman D. V., Baer H. Antibiotic usage and microbial resistance in an intensive care nursery. Am J Dis Child. 1973 Sep;126(3):318–321. doi: 10.1001/archpedi.1973.02110190280006. [DOI] [PubMed] [Google Scholar]
- Guignard J. P., Torrado A., Da Cunha O., Gautier E. Glomerular filtration rate in the first three weeks of life. J Pediatr. 1975 Aug;87(2):268–272. doi: 10.1016/s0022-3476(75)80600-7. [DOI] [PubMed] [Google Scholar]
- Guignard J. P., Torrado A., Mazouni S. M., Gautier E. Renal function in respiratory distress syndrome. J Pediatr. 1976 May;88(5):845–850. doi: 10.1016/s0022-3476(76)81129-8. [DOI] [PubMed] [Google Scholar]
- Haas M. J., Davies J. Enzymatic acetylation as a means of determining serum aminoglycoside concentrations. Antimicrob Agents Chemother. 1973 Oct;4(4):497–499. doi: 10.1128/aac.4.4.497. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Howard J. B., McCracken G. H., Jr Pharmacological evaluation of amikacin in neonates. Antimicrob Agents Chemother. 1975 Jul;8(1):86–90. doi: 10.1128/aac.8.1.86. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Howard J. B., McCraken G. H., Jr, Trujillo H., Mohs E. Amikacin in newborn infants: comparative pharmacology with kanamycin and clinical efficacy in 45 neonates with bacterial diseases. Antimicrob Agents Chemother. 1976 Aug;10(2):205–210. doi: 10.1128/aac.10.2.205. [DOI] [PMC free article] [PubMed] [Google Scholar]
- KORNER P. I. Effects of low oxygen and of carbon monoxide on the renal circulation in unanesthetized rabbits. Circ Res. 1963 Apr;12:361–374. doi: 10.1161/01.res.12.4.361. [DOI] [PubMed] [Google Scholar]
- Karney W., Holmes K. K., Turck M. Comparison of five aminocyclitol antibiotics in vitro against Enterobacteriaceae and Pseudomonas. Antimicrob Agents Chemother. 1973 Mar;3(3):338–342. doi: 10.1128/aac.3.3.338. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kluge R. M., Standiford H. C., Tatem B., Young V. M., Greene W. H., Schimpff S. C., Calia F. M., Hornick R. B. Comparative activity of tobramycin, amikacin, and gentamicin alone and with carbenicillin against Pseudomonas aeruginosa. Antimicrob Agents Chemother. 1974 Oct;6(4):442–446. doi: 10.1128/aac.6.4.442. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Levy J., Klastensky J. Correlation of serum creatinine concentration and amikacin half-life. J Clin Pharmacol. 1975 Oct;15(10):705–707. doi: 10.1002/j.1552-4604.1975.tb05924.x. [DOI] [PubMed] [Google Scholar]
- Marks M. I., Hammerberg S., Greenstone G., Silver B. Activity of newer aminoglycosides and carbenicillin, alone and in combination, against gentamicin-resistant Pseudomonas aeruginosa. Antimicrob Agents Chemother. 1976 Sep;10(3):399–401. doi: 10.1128/aac.10.3.399. [DOI] [PMC free article] [PubMed] [Google Scholar]
- McCracken G. H., Jr, Jones L. G. Gentamicin in the neonatal period. Am J Dis Child. 1970 Dec;120(6):524–533. doi: 10.1001/archpedi.1970.02100110072007. [DOI] [PubMed] [Google Scholar]
- Overturf G. D., Wilkins J., Ressler R. Emergence of resistance of Providencia stuartii to multiple antibiotics: speciation and biochemical characterization of Providencia. J Infect Dis. 1974 Mar;129(3):353–357. doi: 10.1093/infdis/129.3.353. [DOI] [PubMed] [Google Scholar]
- Price K. E., Chisholm D. R., Misiek M., Leitner F., Tsai Y. H. Microbiological evaluation of BB-K 8, a new semisynthetic aminoglycoside. J Antibiot (Tokyo) 1972 Dec;25(12):709–731. doi: 10.7164/antibiotics.25.709. [DOI] [PubMed] [Google Scholar]
- Price K. E., Pursiano T. A., DeFuria M. D. Activity of BB-K8 (amikacin) against clinical isolates resistant to one or more aminoglycoside antibiotics. Antimicrob Agents Chemother. 1974 Feb;5(2):143–152. doi: 10.1128/aac.5.2.143. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Riff L. J., Jackson G. G. Pharmacology of gentamicin in man. J Infect Dis. 1971 Dec;124 (Suppl):S98–105. doi: 10.1093/infdis/124.supplement_1.s98. [DOI] [PubMed] [Google Scholar]
- Sardemann H., Colding H., Hendel J., Kampmann J. P., Hvidberg E. F., Vejlsgaard R. Kinetics and dose calculations of amikacin in the newborn. Clin Pharmacol Ther. 1976 Jul;20(1):59–66. doi: 10.1002/cpt197620159. [DOI] [PubMed] [Google Scholar]
- Stone H. H., Kolb L. D. The evolution and spread of gentamicin-resistant Pseudomonads. J Trauma. 1971 Jul;11(7):586–589. doi: 10.1097/00005373-197107000-00009. [DOI] [PubMed] [Google Scholar]
- THURAU K. RENAL HEMODYNAMICS. Am J Med. 1964 May;36:698–719. doi: 10.1016/0002-9343(64)90181-0. [DOI] [PubMed] [Google Scholar]
- Valdivieso M., Feld R., Rodriguez V., Bodey G. P. Amikacin therapy of infections in neutropenic patients. Am J Med Sci. 1975 Nov-Dec;270(3):453–463. doi: 10.1097/00000441-197511000-00006. [DOI] [PubMed] [Google Scholar]
- Young L. S., Hewitt W. L. Activity of five aminoglycoside antibiotics in vitro against gram-negative bacilli and Staphylococcus aureus. Antimicrob Agents Chemother. 1973 Dec;4(6):617–625. doi: 10.1128/aac.4.6.617. [DOI] [PMC free article] [PubMed] [Google Scholar]
