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. 1977 Jul;12(1):11–15. doi: 10.1128/aac.12.1.11

Human Interferon: Mass Production in a Newly Established Cell Line, MG-63

A Billiau 1, V G Edy 1, Hubertine Heremans 1, J Van Damme 1, J Desmyter 1, J A Georgiades 1, P De Somer 1
PMCID: PMC352146  PMID: 883813

Abstract

MG-63 cells, a line derived from an osteosarcoma, produced high yields of interferon after superinduction with polyinosinic acid·polycytidylic acid, cycloheximide, and actinomycin D. Advantages of MG-63 cells over diploid fibroblasts as a substrate are: no requirement for aging between confluency and induction, no requirement for priming, and 3.7-fold higher yields per square centimeter of culture surface. Physicochemically and biologically, MG-63 cell interferon resembles fibroblast rather than leukocyte interferon.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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