Abstract
Nafcillin, a pencillinase-resistant penicillin, is frequently used for treatment of staphylococcal infections in hemodialysis patients. Despite its widespread use, there is a paucity of available data regarding the pharmacokinetics of nafcillin in hemodialysis patients. Therefore, sodium nafcillin, 25 mg/kg, was given intravenously over a 5- to 15-min period to 12 hemodialysis patients. Eleven patients were studied during dialysis, and eight of these were studied again during the interdialysis period. The initial serum half-life for nafcillin was 0.208 h during dialyses and 0.278 h between dialyses. The terminal half-life was 1.48 h during dialyses and 1.89 h between dialyses. There was no statistically significant difference between these values. These data indicate that renal failure does not appreciably affect the serum half-life of nafcillin, and hemodialysis does not accelerate the rate of clearance of nafcillin from the blood. Therefore, no modification of the usual nafcillin dosage is necessary when using this drug in hemodialysis patients.
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Selected References
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- Bryan C. S., Stone W. J. "Comparably massive" penicillin G therapy in renal failure. Ann Intern Med. 1975 Feb;82(2):189–195. doi: 10.7326/0003-4819-82-2-189. [DOI] [PubMed] [Google Scholar]
- Fossieck B., Jr, Parker R. H. Neurotoxicity during intravenous infusion of penicillin. A review. J Clin Pharmacol. 1974 Oct;14(10):504–512. doi: 10.1002/j.1552-4604.1974.tb01364.x. [DOI] [PubMed] [Google Scholar]
- GREEN G. R., GERACI J. E. A NOTE ON THE CONCENTRATION OF NAFCILLIN IN HUMAN BILE. Mayo Clin Proc. 1965 Sep;40:700–704. [PubMed] [Google Scholar]
- KLEIN J. O., FINLAND M. NAFCILLIN. ANTIBACTERIAL ACTION IN VITRO AND ABSORPTION AND EXCRETION IN NORMAL YOUNG MEN. Am J Med Sci. 1963 Jul;246:10–26. doi: 10.1097/00000441-196307000-00002. [DOI] [PubMed] [Google Scholar]
- Kind A. C., Tupasi T. E., Standiford H. C., Kirby W. M. Mechanisms responsible for plasma levels of nafcillin lower than those of oxacillin. Arch Intern Med. 1970 Apr;125(4):685–690. [PubMed] [Google Scholar]
- Riegelman S., Loo J. C., Rowland M. Shortcomings in pharmacokinetic analysis by conceiving the body to exhibit properties of a single compartment. J Pharm Sci. 1968 Jan;57(1):117–123. doi: 10.1002/jps.2600570123. [DOI] [PubMed] [Google Scholar]
- Rudnick M., Morrison G., Walker B., Singer I. Renal failure, hemodialysis, and nafcillin kinetics. Clin Pharmacol Ther. 1976 Oct;20(4):413–423. doi: 10.1002/cpt1976204413. [DOI] [PubMed] [Google Scholar]